照亮Treg细胞再编程用于癌症治疗。
Shining light on reprogramming Tregs for cancer therapy.
发表日期：2023 Mar 16
作者：
Eric S Wang, Nathanael S Gray
来源：
Cell Chemical Biology
摘要：
在这一期的《细胞化学生物学》中，Bonazzi等人表明，药物降解转录因子Helios（IKZF2）会导致调节性T细胞不稳定，这些细胞通常能够抑制抗肿瘤免疫。这些结果强调了分子胶降解剂如何能够有选择地作用于以前无法靶向的蛋白质，并在临床中具有潜在应用。版权所有 © 2023 Elsevier Ltd.。
In this issue of Cell Chemical Biology, Bonazzi et al. demonstrate that pharmacologically degrading the transcription factor Helios (IKZF2) results in destabilization of regulatory T cells, which normally restrain anti-tumor immunity. These results highlight how molecular glue degraders can selectively target previously undruggable proteins with potential applications in the clinic.Copyright © 2023 Elsevier Ltd. All rights reserved.