IFN-γ信号通路相关基因的突变使肿瘤对免疫检查点阻滞更敏感。
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade.
发表日期：2023 Feb 23
作者：
Eric Song, Ryan D Chow
来源：
CANCER CELL
摘要：
Song和Chow展示了在体外共培养系统中，肿瘤内的IFN-γ信号通路突变会导致免疫抵抗力，但这些变化与体内增强的抗肿瘤免疫力和在癌症患者中对免疫检查点阻断治疗的反应性改善相关。版权所有©2023 Elsevier Inc.保留所有权利。
Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced anti-tumor immunity in vivo and improved responsiveness to immune checkpoint blockade therapy in patients with cancer.Copyright © 2023 Elsevier Inc. All rights reserved.