胰岛素/胰岛素样生长因子1（IGF1）通路正在成为前列腺癌进展的关键组成部分。因此，我们调查了新型胰岛素/IGF1信号调节剂-内受体在前列腺癌中的作用。我们分析了内受体在人类良性前列腺上皮和前列腺癌症样本中的表达。此外，我们使用前列腺癌细胞系进行信号传递和功能分析。我们发现内受体在人类良性和恶性前列腺组织中均有表达，并且其表达与多种感兴趣的基因呈正相关，包括与雄激素信号有关的基因。在体外，雄激素剥夺后内受体的总水平增加，并与核内高水平的雄激素受体相关。内受体过度表达与细胞迁移增加、IGF1R转运变化和IGF1R激活增加相关。我们的体外结果表明，内受体表达与雄激素状态、细胞迁移增加和IGF1R信号有关。在人类样本中，内受体表达与前列腺癌进展标志物显著相关。综上所述，这些数据为在前列腺癌情境下研究内受体提供了基础。版权所有©2023 Elsevier GmbH发表。

The insulin/insulin-like growth factor 1 (IGF1) pathway is emerging as a crucial component of prostate cancer progression. Therefore, we investigated the role of the novel insulin/IGF1 signaling modulator inceptor in prostate cancer.We analyzed the expression of inceptor in human samples of benign prostate epithelium and prostate cancer. Further, we performed signaling and functional assays using prostate cancer cell lines.We found that inceptor was expressed in human benign and malignant prostate tissue and its expression positively correlated with various genes of interest, including genes involved in androgen signaling. In vitro, total levels of inceptor were increased upon androgen deprivation and correlated with high levels of androgen receptor in the nucleus. Inceptor overexpression was associated with increased cell migration, altered IGF1R trafficking and higher IGF1R activation.Our in vitro results showed that inceptor expression was associated with androgen status, increased migration, and IGF1R signaling. In human samples, inceptor expression was significantly correlated with markers of prostate cancer progression. Taken together, these data provide a basis for investigation of inceptor in the context of prostate cancer.Copyright © 2023. Published by Elsevier GmbH.