癌症幸存者承担的总发病率负担的全面评估仍无法获得。本研究评估了243,767位成人中26种成人癌症和治疗方法中的144种健康状况和重症监护入院负担。60岁时，按倍数差（幸存者中的累积负担与对照组中的累积负担相除）排名前三的疾病为血液学、免疫/感染和肺部疾病。接受化疗、放疗和手术三种治疗的患者与仅接受放疗的患者相比，晚期发病率的累积负担较高。60岁时，累积重症监护入院负担最高的前五种癌症为骨癌（100人中12.4次[CI：11.6-13.1]），脑癌（9.0次[7.5-10.5]），脊髓和神经系统（7.2次[6.7-7.8]），睾丸癌（6.7次[4.9-8.4]）和霍奇金淋巴瘤（4.4次[3.6-5.1]）。与高额失年寿命相关的疾病为血液学疾病（9.6年），肺部疾病（8.6年）和免疫性疾病或感染（7.8年）。随着癌症幸存者人口的不断增长，我们的研究结果表明，通过实施数据驱动的政策解决长期健康后果变得越来越重要。 ©2023. 作者。

A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health conditions and critical care admissions across 26 adult cancers and treatment modalities in 243,767 adults. By age 60, top conditions ranked by fold difference (cumulative burden in survivors divided by cumulative burden in controls) were haematology, immunology/infection and pulmonary conditions. Patients who had all three forms of treatment (chemotherapy, radiotherapy and surgery) experienced a high cumulative burden of late morbidities compared with patients who received radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions by age 60 were bone (12.4 events per 100 individuals [CI: 11.6-13.1]), brain (9.0 [7.5-10.5]), spinal cord and nervous system (7.2 [6.7-7.8]), testis (6.7 [4.9-8.4]) and Hodgkin lymphoma (4.4 [3.6-5.1]). Conditions that were associated with high excess years-of-life-lost were haematological conditions (9.6 years), pulmonary conditions (8.6 years) and immunological conditions or infections (7.8 years). As the population of cancer survivors continues to grow, our results indicate that it is important to tackle long-term health consequences through enacting data-driven policies.© 2023. The Author(s).