研究动态
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非霍奇金淋巴瘤对骨髓的浸润:三级保健中心的经验。

Bone marrow infiltration by Non-Hodgkin lymphoma: An experience in a tertiary care centre.

发表日期:2023 Mar
作者: Maymoona Suhail, Asad Mahmood, Rafia Mahmood, Saima Zahir, Syeda Samia Shafaat, Sumaira Illyas
来源: Bone & Joint Journal

摘要:

确定非何杰金淋巴瘤患者骨髓浸润的频率和模式。这项横断面研究于2021年4月至10月在巴基斯坦拉瓦尔品第武装力量病理研究所进行,涉及20至80岁的男女患者,均已被诊断为非何杰金淋巴瘤。按标准协议进行骨髓穿刺和骨髓穿刺活检,从后上髂嵴处获取所有患者的骨髓涂片进行评估。使用SPSS 25分析数据。其中,100名患者中,男性67例(67%),女性33例(33%)。总平均年龄为54.99±12岁,平均症状持续时间为11.7±1.5个月。弥漫大B细胞淋巴瘤是最常见的类型,占43(43%)例。38(38%)例出现骨髓浸润,其中12(12%)例为套膜细胞淋巴瘤。最常见的浸润模式为17(17%)例的弥漫型,其次是10(10%)例的局灶/结节型。发现弥漫大B细胞淋巴瘤是非何杰金淋巴瘤最常见的类型,而骨髓浸润最常见于套膜细胞淋巴瘤病例中。
To determine the frequency and patterns of bone marrow infiltration in non-Hodgkin lymphoma patients.The cross-sectional study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from April to October 2021, and comprised patients of either gender aged 20-80 years who had been diagnosed with non-Hodgkin lymphoma. Following assessment and as per standard protocol, bone marrow aspirate and trephine biopsy were done on all patients from the posterior superior iliac spine, and slides were prepared and assessed. Data was analysed using SPSS 25.Of the 100 patients, 67(67%) were males and 33(33%) were females. The overall mean age was 54.99±12 years, and mean duration of symptoms was 11.7±1.5 months. Diffuse large B-cell lymphoma was the commonest type 43(43%). Infiltration of marrow occurred in 38(38%) patients, with 12(12%) of them being cases of mantle cell lymphoma. The commonest infiltration pattern was diffuse in 17(17%) cases, followed by focal/nodular in 10(10%).Diffuse large B-cell lymphoma was found to be the commonest type of non-Hodgkin lymphoma, and marrow infiltration occurred most frequently in cases of mantle cell lymphoma.