罕见花素A-E，来自于Centrapalus pauciflorus的非预期香豆素-单萜类类半萜类。
Pauciflorins A-E, Unexpected Chromone-Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus.
发表日期：2023 Mar 18
作者：
Gordana Krstić, Muhammad Bello Saidu, Petra Bombicz, Sourav De, Hazhmat Ali, István Zupkó, Róbert Berkecz, Umar Shehu Gallah, Dóra Rédei, Judit Hohmann
来源：
JOURNAL OF NATURAL PRODUCTS
摘要：
根据新碳骨架，通过多步色谱分离从少花十字花属Centrapalus pauciflorus空气部分的甲醇提取物中分离出五种非同寻常的植物萜化合物，即pauciflorin A-E（1-5），其中，化合物1-3由2-去氢色酮和单萜基团连接而成，而4和5是具有罕见的正酯功能的二氢色酮-单萜加合物。这些结构是使用一维和二维核磁共振、高分辨质谱和单晶X射线衍射解决的。对人类妇科癌细胞系进行抗增生活性评估，但这些化合物在每种情况下均未活性（IC50 < 10μM）。
Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A-E (1-5), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of Centrapalus pauciflorus. Compounds 1-3 are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas 4 and 5 are dihydrochromone-monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A-E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC50 < 10 μM) in each case.