有机体的伴随系统（CS）由分子伴随体，伴随体辅因子，共伴随体和伴随体受体以及相互作用体组成。它存在于全身，但每个细胞和组织类型都有独特的特征。先前关于唾液腺 CS 的研究已确定了几种成员在正常和病态腺体中的数量和分布模式，重点关注肿瘤。伴随体具有细胞保护作用，但也可能成为病因，引起伴随体病。一些伴随体如 Hsp90 可促进肿瘤的生长，增殖和转移。在伴随体组织中有关 Hsp90 的定量数据，包括有炎症、良性和恶性肿瘤，表明评估组织 Hsp90 水平和分布模式对于分化诊断-预后和患者随访是有用的。反过来，这将为基于伴随体的特异性治疗提供线索，例如通过抑制其致癌功能（负面伴随治疗）。在这里，我们回顾了 Hsp90 的致癌机制和其抑制剂的数据。 Hsp90 是促进肿瘤细胞增殖和转移的 PI3K-Akt-NF-kB 轴的主要调节因子。我们讨论了涉及这些分子复合物的通路和相互作用，以及已经测试过寻找有效抗癌药物的 Hsp90 抑制剂。鉴于其理论潜力和一些积极的实际结果，以及考虑到唾液腺和其他组织的肿瘤需要新的治疗方法，这种靶向治疗值得进行广泛的研究。© 2023年作者（们）。

The chaperone system (CS) of an organism is composed of molecular chaperones, chaperone co-factors, co-chaperones, and chaperone receptors and interactors. It is present throughout the body but with distinctive features for each cell and tissue type. Previous studies pertaining to the CS of the salivary glands have determined the quantitative and distribution patterns for several members, the chaperones, in normal and diseased glands, focusing on tumors. Chaperones are cytoprotective, but can also be etiopathogenic agents causing diseases, the chaperonopathies. Some chaperones such as Hsp90 potentiate tumor growth, proliferation, and metastasization. Quantitative data available on this chaperone in salivary gland tissue with inflammation, and benign and malignant tumors suggest that assessing tissue Hsp90 levels and distribution patterns is useful for differential diagnosis-prognostication, and patient follow up. This, in turn, will reveal clues for developing specific treatment centered on the chaperone, for instance by inhibiting its pro-carcinogenic functions (negative chaperonotherapy). Here, we review data on the carcinogenic mechanisms of Hsp90 and their inhibitors. Hsp90 is the master regulator of the PI3K-Akt-NF-kB axis that promotes tumor cell proliferation and metastasization. We discuss pathways and interactions involving these molecular complexes in tumorigenesis and review Hsp90 inhibitors that have been tested in search of an efficacious anti-cancer agent. This targeted therapy deserves extensive investigation in view of its theoretical potential and some positive practical results and considering the need of novel treatments for tumors of the salivary glands as well as other tissues.© 2023. The Author(s).