作为一种常见的类黄酮醇，卡培酮（Kae）因其具有抗炎、抗氧化和抗癌等特性，在健康食品和医药领域有广泛的市场。在本研究中，我们开发了一种基于碳点（CDs）的新型便捷简易荧光探针，用于检测Kae。具有优异荧光发射（PL）和上转换发光（UCPL）性能的荧光CDs通过用抗坏血酸作为碳源，在90℃的低温油浴反应条件下，用一锅法成功合成。在最佳条件下，CDs的荧光强度随着Kae的加入而逐渐猝灭，F0/F与Kae浓度在5 µM至100 µM范围内呈线性关系，检测限为0.38 µM。这种设计的探针成功应用于实际样品（新达康片剂）中检测Kae。此外，由于其操作简便、材料经济、环保、设备要求低以及快速检测等优点，所提出的CDs在作为检测Kae的药物探针方面具有巨大的应用前景。 © 2023年作者, 在Springer Science+Business Media, LLC, part of Springer Nature独家许可下。

As a common flavonols, kaempferol (Kae) has a broad market as health food and medicine for its anti-inflammatory, anti-oxidation, and anti-cancer properties. In this study, a novel convenient and simple fluorescent sensor based on carbon dots (CDs) for the detection of Kae was developed. The fluorescent CDs, with excellent photo-luminescence (PL) and up-conversion luminescence (UCPL) properties, were successfully prepared by low-temperature oil bath reaction based on ascorbic acid as carbon source at 90 °C in one pot. Under the optimal conditions, the fluorescence (FL) intensity of CDs was gradually quenched by the increasing addition of Kae with a linear relationship between F0/F and Kae concentration in a wide range from 5 µM to 100 µM with a detection limit of 0.38 µM. And this designed sensor was favourably applied for the detection of Kae in actual sample (xin-da-kang tablets). Moreover, the proposed CDs has great application prospects as a drug-sensor for detecting Kae due to its simple operation, economical and green materials, low equipment requirement, and rapid detection.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.