为探讨综合康复治疗在慢性阻塞性肺疾病（COPD）中的价值及其对患者炎症改善的影响，选取了2020年3月至2022年1月中国河北大学附属医院174名急性COPD加重患者作为研究对象，按照随机数字表法分为对照组、急性组和稳定组（每组n=58）。对照组接受常规治疗，急性组在急性期开始综合康复治疗，稳定组在经常规治疗稳定病情后进入稳定期开始综合康复治疗。测量治疗前后肿瘤坏死因子-α（TNF-α）、高敏C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和肺功能，并测量1秒用力呼气容积（FEV1）、1秒用力呼气容积/用力肺活量比（FEV1/FVC）和峰值呼气流量（PEF）。对患者进行6分钟步行测试（6MWD），使用日常生活活动评定（ADL）、自评焦虑量表（SAS）和自评抑郁量表（SDS）评估患者的日常生活能力和心理状态。最后，记录患者的不良事件发生率（AEs）并完成生活质量（QoL）调查。 急性组和稳定组的6MWD测试、ADL、FEV1、FEV1/FVC和PEF均较对照组提高，而呼吸急促、TNF-α、hs-CRP和IL-6较对照组减少（P < .05）。治疗后急性组和稳定组的SAS和SDS评分降低（P < .05），而对照组无变化（P > .05）。此外，急性组和稳定组的QoL较高（P < .05）。急性组的所有指标改善优于稳定组（P < .05）。综合康复治疗可以提高COPD患者的运动能力和肺功能，减少炎症，改善患者的负面心理。

To investigate the value of comprehensive rehabilitation therapy in chronic obstructive pulmonary disease (COPD) and its effect on improvement in patients' inflammation.A total of 174 patients with acute COPD exacerbation in the Affiliated Hospital of Hebei University in China from March 2020 to January 2022 were selected as research subjects. They were divided into control, acute and stable groups according to the random number table method (n=58 in each group). The control group was given conventional treatment; the acute group started comprehensive rehabilitation treatment in the acute phase; in the stable group, comprehensive rehabilitation treatment was initiated in the stable period after the condition was stabilized with conventional treatment. Tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and pulmonary function were measured before and after treatment, with the forced expiratory volume in 1 second (FEV1), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio, and peak expiratory flow rate (PEF). A 6-min walk test (6MWD) was performed on the patient, and the ability to perform activities of daily living (ADL), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess patients' ability to perform ADL and psychology. Finally, the incidence of adverse events (AEs) in patients was recorded and a quality of life (QoL) survey was completed.The 6MWD test, ADL, FEV1, FEV1/FVC and PEF were elevated in the acute and stable groups compared with the control group, whereas shortness of breath, TNF-α, hs-CRP and IL-6 were decreased (P < .05). SAS and SDS scores were reduced in the acute and stable groups after treatment (P < .05), while there was no change in the control group (P > .05). In addition, QoL was higher in the acute and stable groups (P < .05). The improvement of all indicators in the acute group was better than in the stable group (P < .05).Comprehensive rehabilitation therapy can improve the exercise capacity and lung function of patients with COPD, reduce inflammation, and improve patients' negative psychology.