单克隆球蛋白表型未定（MGUS）是一种未发生明显症状的前恶性浆细胞疾病，但存在较高的静脉血栓栓塞（VTE）风险。我们进行了一项以人群为基础的研究，以调查这些患者患VTE的风险。我们利用2016年的国家住院样本（NIS）比较了携带MGUS诊断和不携带该诊断的患者之间急性VTE发生率的差异。我们排除了年龄小于18岁和已被诊断为淋巴瘤、白血病、实体肿瘤或其他浆细胞异常病的住院患者。我们利用ICD-10-CM编码系统搜索数据库以获得VTE、MGUS和其他并发症的代码。采用多元逻辑回归模型进行比较分析，根据人口特征和并发症进行调整。以分类变量的频率和比例以及连续变量的中位数和四分位距来描述基线并发症。MGUS组共有33,115个加权住院患者。这些患者与不携带MGUS诊断的27,418,403个加权住院患者进行了比较。MGUS组患者发生复合性VTE（根据研究调整的OR 1.33，95% CI为1.22-1.44）、深静脉血栓（根据研究调整的OR 1.46，95% CI为1.29-1.65）和肺栓塞（根据研究调整的OR 1.22，95% CI为1.09-1.37）的概率更高。与没有MGUS病史的患者相比，患有MGUS的患者发生急性静脉血栓栓塞的几率更高。©2023 Elsevier Ltd。保留所有权利。

Monoclonal Gammopathy of Undetermined Significance (MGUS) is a premalignant plasma cell disorder which despite being clinically silent carries an increased risk of venous thromboembolism (VTE). We conducted a population-based study to investigate the risk of VTE in these patients.We utilized the National Inpatient Sample (NIS) for the year 2016 to compare the incidence of acute VTE between patients who carry the diagnosis of MGUS and those who don't. We excluded hospitalizations with age < 18 years and those that had a diagnosed lymphoma, leukemia, solid malignancy, or other plasma cell dyscrasia. We utilized the ICD-10-CM coding system to search the database for codes of VTE, MGUS, and other comorbid conditions. Multivariate logistic regression models were used for comparative analysis adjusting for demographic characteristics and comorbidities. Baseline comorbidities were described as frequencies and proportions for categorical variables and as medians with interquartile ranges for continuous variables.A total of 33,115 weighted hospitalizations were included in the MGUS group. These were compared to 27,418,403 weighted hospitalizations without the diagnosis of MGUS. The MGUS group had higher odds of composite venous thromboembolism (adjusted OR 1.33, 95 % CI 1.22-1.44), deep vein thrombosis (adjusted OR 1.46, 95 % CI 1.29-1.65), and pulmonary embolism (adjusted OR 1.22, 95 % CI 1.09-1.37).Patients with MGUS had increased odds of developing acute venous thromboembolism compared to patients with no history of MGUS.Copyright © 2023 Elsevier Ltd. All rights reserved.