癌症转移的治疗与癌细胞的进展显著减少和患者生存率的提高有关。由于90%的死亡是由于癌症转移，抑制癌症转移可以提高癌症抗击能力。EMT 是癌细胞转移的潜在原因，随后是上皮细胞的间充质转化。HCC 是主要的肝肿瘤，危及世界各地许多人的生命，预后不佳。通过抑制肿瘤转移可以提高患者预后。本文讨论了纳米颗粒对 HCC 转移和 EMT 治疗的调节。首先，EMT 发生在 HCC 的进展和晚期阶段，因此抑制它可以减少肿瘤的恶性程度。此外，抗癌化合物包括全反式维甲酸和钉锋锡等被认为是 EMT 的抑制剂。EMT 与化疗抗性的关联也得到了评估。此外，ZEB1/2、TGF- β、蜗牛和扭曲是 HCC 中的 EMT 调节因子，可增强癌症侵袭。因此，本文评估了 HCC 中 EMT 机制和相关分子机制。治疗 HCC 不仅强调靶向分子途径的药理化合物，由于药物生物可利用性低，纳米颗粒的靶向输送促进了 HCC 的消除。此外，纳米颗粒介导的光疗通过触发细胞死亡来破坏 HCC 的肿瘤发生。HCC 甚至 EMT 机制的转移都可以通过装载货物的纳米颗粒来抑制。版权所有©2023年Elsevier Inc.

Management of cancer metastasis has been associated with remarkable reduction in progression of cancer cells and improving survival rate of patients. Since 90% of mortality are due to cancer metastasis, its suppression can improve ability in cancer fighting. The EMT has been an underlying cause in increasing cancer migration and it is followed by mesenchymal transformation of epithelial cells. HCC is the predominant kind of liver tumor threatening life of many people around the world with poor prognosis. Increasing patient prognosis can be obtained via inhibiting tumor metastasis. HCC metastasis modulation by EMT and HCC therapy by nanoparticles are discussed here. First of all, EMT happens during progression and advanced stages of HCC and therefore, its inhibition can reduce tumor malignancy. Moreover, anti-cancer compounds including all-trans retinoic acid and plumbaging, among others, have been considered as inhibitors of EMT. The EMT association with chemoresistance has been evaluated. Moreover, ZEB1/2, TGF-β, Snail and Twist are EMT modulators in HCC and enhancing cancer invasion. Therefore, EMT mechanism and related molecular mechanisms in HCC are evaluated. The treatment of HCC has not been only emphasized on targeting molecular pathways with pharmacological compounds and since drugs have low bioavailability, their targeted delivery by nanoparticles promotes HCC elimination. Moreover, nanoparticle-mediated phototherapy impairs tumorigenesis in HCC by triggering cell death. Metastasis of HCC and even EMT mechanism can be suppressed by cargo-loaded nanoparticles.Copyright © 2023. Published by Elsevier Inc.