Arsenic resistance protein 2 (Ars2)是一种核蛋白，对microRNA（miRNA）的生物合成调控发挥关键作用。Ars2对于细胞增殖和哺乳动物发育的早期阶段至关重要，可能通过影响miRNA的处理发挥作用。越来越多的证据表明，在增殖的癌细胞中Ars2高度表达，这表明Ars2可能是癌症的潜在治疗靶点。因此，开发新型Ars2抑制剂可能代表治疗癌症的新的治疗策略。在本综述中，我们简要讨论Ars2如何调节miRNA生物合成以及其对细胞增殖和癌症发展的影响。特别地，我们主要讨论Ars2在癌症发展中的作用，并强调把Ars2作为有前途的癌症治疗策略进行药物靶向治疗。版权所有©2023。Elsevier公司发表。

Arsenic resistance protein 2 (Ars2) is a nuclear protein that plays a critical role in the regulation of microRNA (miRNA) biogenesis. Ars2 is required for cell proliferation and for the early stages of mammalian development through a possible effect on miRNA processing. Increasing evidence reveal that Ars2 is highly expressed in proliferating cancer cells, suggesting that Ars2 may be a potential therapeutic target for cancer. Therefore, development of the novel Ars2 inhibitors could represent the novel therapeutic strategies for treatment of cancer. In this review, we briefly discuss the mechanisms by which Ars2 regulates miRNA biogenesis and its impact on cell proliferation and cancer development. Particularly, we mainly discuss the role of Ars2 in the regulation of cancer development and highlight pharmacological targeting of Ars2 as a promising cancer therapeutic strategy.Copyright © 2023. Published by Elsevier Inc.