开发和测试口服抗癌药物自我护理指数（SCOAAI）的内容效度。根据基于共识的健康测量仪器选择标准（COSMIN）标准开发SCOAAI项目。自我慢性病护理中程理论指导项目生成。按照四个阶段程序进行；第一阶段：根据先前的系统评价和定性研究创建项目；第二阶段：通过定性的医学专家和患者的访谈，建立SCOAAI的可理解性和全面性（第三阶段）；第四阶段：通过在线调查向临床专家组提供SCOAAI以计算内容效度指数（CVI）。 SCOAAI的第一个版本包括27个项目。五名临床专家和10名患者测试了说明、项目和响应选项的全面性和可理解性。53名专家（71.7％女性，口服抗癌药物经验平均5.8年[标准偏差±0.2]，66％为护士）参加了在线调查以测试内容效度。SCOAAI的最终版本包括32个项目。项目CVI范围为0.79至1；平均标度CVI为0.95。未来的研究将测试该工具的心理测量特性。 SCOAAI展示出非常好的内容效度，证实了其在评估口服抗癌药物患者的自我护理行为方面的有用性。通过实施此工具，护士可以确定并实施有针对性的干预措施，以改善自我护理并获得更积极的结果（例如更好的生活质量，减少住院和急诊访问）。版权所有©2023 Elsevier Inc.。保留所有权利。

To develop and test the content validity of the Self-Care of Oral Anticancer Agents Index (SCOAAI).SCOAAI items were developed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. The Middle Range Theory of Self-Care of Chronic Illnesses informed item generation. A four-phase procedure was followed; Phase 1: items were created based on a previous systematic review and a qualitative study; Phase 2: the SCOAAI comprehensibility and comprehensiveness were established through qualitative interviews with clinical experts and with patients (Phase 3); and Phase 4: the SCOAAI was then administered through an online survey to a group of clinical experts for the Content Validity Index (CVI) calculation.The first version of the SCOAAI included 27 items. Five clinical experts and 10 patients tested the comprehensiveness and comprehensibility of instructions, items, and response options. Fifty-three experts (71.7% female, mean experience with patients on oral anticancer agents 5.8 years [standard deviation ± .2]; 66% nurses) participated in the online survey for content validity testing. The final version of the SCOAAI includes 32 items. Item CVI ranges between 0.79 and 1; the average Scale CVI is 0.95. Future studies will test the psychometric properties of the tool.The SCOAAI showed excellent content validity, confirming its usefulness for assessing self-care behaviors for patients on oral anticancer agents. By implementing this instrument, nurses could define and implement targeted interventions for improving self-care and obtaining more positive outcomes (eg, better quality of life, reduced hospitalizations and emergency department visits).Copyright © 2023 Elsevier Inc. All rights reserved.