Cadherin的顺式和反式相互作用确保多细胞体。虽然Cadherin的反式相互作用的分子结构已经被广泛了解，但鉴定能扩散顺式相互作用的分子信号仍在研究中。我们报道了在溶液中液-液相分离的生物分子过渡、弱、但多价和在空间上分布的疏水相互作用就可以单独地促进膜上Cadherin-23的侧向聚集。侧向聚集并不需要特定的顺式二聚体作用。细胞中，顺式聚集加速了细胞间黏附，从而贡献于细胞黏附动力学，同时也增强了结合。虽然顺式聚集与快速黏附的生理联系尚待探索，但我们猜测，M2型巨噬细胞中Cadherin-23的过表达可能有助于在转移时更快地与循环肿瘤细胞结合。© 2023. The Author(s).

Cis and trans-interactions among cadherins secure multicellularity. While the molecular structure of trans-interactions of cadherins is well understood, work to identify the molecular cues that spread the cis-interactions two-dimensionally is still ongoing. Here, we report that transient, weak, yet multivalent, and spatially distributed hydrophobic interactions that are involved in liquid-liquid phase separations of biomolecules in solution, alone can drive the lateral-clustering of cadherin-23 on a membrane. No specific cis-dimer interactions are required for the lateral clustering. In cells, the cis-clustering accelerates cell-cell adhesion and, thus, contributes to cell-adhesion kinetics along with strengthening the junction. Although the physiological connection of cis-clustering with rapid adhesion is yet to be explored, we speculate that the over-expression of cadherin-23 in M2-macrophages may facilitate faster attachments to circulatory tumor cells during metastasis.© 2023. The Author(s).