放射治疗是癌症治疗中最重要的手段之一，但辐射也会对皮肤造成不良反应甚至严重伤害。与正常皮肤受伤相比，辐射引起的过量活性氧自由基（ROS）和炎症细胞浸润使皮肤伤口难以愈合。因此，我们设计了一种抗氧化肝素类肽水凝胶（K16，KYKYEYEYAGEGDSS-4Sa）用于放射性皮肤损伤修复。首先，K16肽能够自组装成三维网状多孔纳米纤维结构的水凝胶，类似于细胞外基质（ECM），为皮肤修复提供一定的物理支持。然后，K16水凝胶不仅能清除ROS并防止辐射对细胞DNA的损伤，还能促进细胞增殖、迁移和血管生成。同时，4-磺基苯甲酸（4Sa）修饰在K16肽的N端，能够吸附炎症细胞因子，从而消除伤口部位的炎症。体内实验表明，K16水凝胶能够抑制早期伤口降解，减少炎症浸润，促进血管生成和胶原沉积，从而促进伤口愈合。因此，本研究设计的K16水凝胶在放射性皮肤损伤修复领域具有良好的应用潜力。本文受版权保护。保留所有权利。

Radiotherapy is one of the most important means of cancer treatment, however, radiation can also cause adverse reactions and even serious injuries to the skin. Radiation-induced excess reactive oxygen species (ROS) production and inflammatory infiltration make skin wounds difficult to heal compared to normal skin injuries. Herein, we designed an antioxidant heparin-mimetic peptide hydrogel (K16, KYKYEYEYAGEGDSS-4Sa) for radiation-induced skin injury repair. First, K16 peptide can self-assemble into a hydrogel with a three-dimensional mesh-like porous nanofiber structure, which can provide certain physical support for skin repair like extracellular matrix (ECM). Then, K16 hydrogel not only scavenges ROS and prevents radiation damage to cellular DNA, but also promotes cell proliferation, migration and angiogenesis. Meanwhile, 4-Sulfobenzoic acid (4Sa) modified at the N-terminal end of K16 peptide can adsorb inflammatory cytokines, thus acting to eliminate inflammation at the wound site. In vivo experiments showed that K16 hydrogel can inhibit early wound degradation, reduce inflammatory infiltration, promote angiogenesis and collagen deposition, thus promoting wound healing. Therefore, the K16 hydrogel designed in this study has good potential for application in the field of radiation-induced skin injury repair. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.