酒精使用障碍 (AUD) 是双相情感障碍 (BD) 患者中高度流行的共病障碍，BD 和 AUD 均被发现与炎症和认知缺陷有关，但对 BD+AUD（BD 伴随 AUD）的研究很少。我们旨在研究共病 AUD 和 BD 对认知功能，炎症和神经营养标志物的影响。我们招募了641名 BD 患者，150名 BD+AUD 患者和185名健康对照组 (HC)。对神经心理学测试 [威斯康星卡片分类测试 (WCST)，连续执行测试 (CPT) 和韦氏记忆量表-第三版 (WMS-III)] 和细胞因子血浆水平 [肿瘤坏死因子-α (TNF-α)，C-反应蛋白 (CRP)，白细胞介素-8 (IL-8)，转化生长因子-β1 (TGF-β1) 和脑源性神经营养因子 (BDNF)] 进行了评估。BD+AUD 患者的认知表现比没有 AUD 的患者更差。在血浆水平上，患者组与 HC 组之间的 TNF-α、IL-8 和 BDNF 水平存在显著差异 (P < 0.001，<0.001 和 0.01)，事后分析显示 BD+AUD 患者的 TNF-α 和 IL-8 水平高于仅有 BD 的患者 (P < 0.001)。此外，血浆 IL-8 水平与 WCST 中完成类别数量呈负相关 (P = 0.02)，而 TNF-α 水平与 WMS-III 中视觉直接指数呈负相关 (P = 0.05)。我们的结果表明，共病 AUD 和 BD 可能会加重认知障碍和炎症过程。需要进一步进行 BD+AUD 的纵向研究。Copyright © 2023 Elsevier Ltd. All rights reserved.

Alcohol use disorder (AUD) is a highly prevalent comorbid disorder in patients with bipolar disorder (BD). Both BD and AUD were found to be associated with inflammation and cognitive deficits, but few study has been done on BD comorbid with AUD (BD+AUD). We aimed to investigate the impacts of comorbid AUD and BD on cognitive function, inflammatory and neurotrophic markers.We recruited 641 BD patients, 150 patients with BD+AUD, and 185 healthy controls (HC). Neuropsychological tests [Wisconsin card sorting test (WCST), continuous performance test (CPT), and Wechsler memory scale - third edition (WMS-III)] and cytokine plasma levels [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-8 (IL-8), transforming growth factor-β1 (TGF-β1), and brain-derived neurotrophic factor (BDNF)] were assessed.BD+AUD patients had worse cognitive performance than those without AUD. There was a significant difference in the plasma levels of TNF-α, IL-8, and BDNF (P < 0.001, <0.001, and 0.01, respectively) between the patients and the HC groups. Post hoc analysis showed that BD+AUD patients had higher levels of TNF-α and IL-8 than BD-only patients (P < 0.001). Additionally, plasma IL-8 levels were negatively associated with number of completed categories in WCST (P = 0.02), and TNF-α levels were negatively associated with visual immediate index in WMS-III (P = 0.05).Our results suggest that comorbid AUD and BD might worsen cognitive impairments and inflammatory processes. Further longitudinal studies on BD+AUD may be needed.Copyright © 2023 Elsevier Ltd. All rights reserved.