目的：研究非霍奇金淋巴瘤（NHL）并发妊娠的临床病理学特征、诊断、治疗与预后。方法：回顾性分析2010年1月至2022年5月在南京鼓楼医院收治的7例NHL并发妊娠患者的临床病理资料，分别分析患者一般情况、诊断、治疗以及母婴预后。结果：（1）7例患者的中位年龄为28岁（范围：26-33岁）；3例患者有腹部疼痛（2例为巨大盆腔或腹部肿块并有多发转移），2例为咳嗽（1例合并上腔静脉综合征），1例为面部肿胀和疼痛，1例为食欲不振。从症状出现到初诊的中位时间为30天（范围：15-188天）。 （2）只有3例患者在妊娠期通过活检确诊，其中包括右鼻前庭肿块、左锁骨上淋巴结和肺部的活检。一例患者在妊娠期间通过骨髓穿刺怀疑脾边缘区淋巴瘤，术后脾切除标本病理结果证实。另外3例患者是通过剖腹产中病变灶活检或肿瘤局部切除标本的病理结果明确为NHL。病理类型：5例弥漫性大B细胞淋巴瘤，1例脾边缘区淋巴瘤和1例鼻腔自然杀伤（NK）/ T细胞淋巴瘤。分期：1例Ⅱ期，6例Ⅳ期。其中4例於分娩後 进行胎盘病理检查，其中1例胎盘转移。 （3）在7例患者中，1例在第二孕期诱导分娩，5例在第三孕期通过剖腹产终止妊娠，全部为早产；1例通过钳刀助产分娩。6名新生儿全部健康存活。治疗：5例患者在终止妊娠后接受了化疗（其中1例接受了自体造血干细胞重输后化疗），1例患者在化疗中辅以鼻咽部放疗，6例患者无复发存活（截至2022年10月随访）。另外1例患有乙型肝炎病毒感染和先天性心脏病的患者，在剖腹产后18天因多器官衰竭死亡。结论：NHL并发妊娠具有诊断难度，应注意孕妇的症状，积极进行相关检查；当病变涉及多个器官时应考虑淋巴瘤的可能性。对于NHL并发妊娠，化疗具有较好疗效，即使对于晚期患者，在标准化治疗后也能获得良好的治疗效果。

Objective: To investigate the clinicopathological features, diagnosis, treatment and outcomes of pregnancy with non-Hodgkin lymphoma (NHL). Methods: The clinicopathological data of 7 patients of pregnancy with NHL admitted to Nanjing Drum Tower Hospital from January 2010 to May 2022 were reviewed. General information, diagnosis, treatment and maternal and child outcomes were retrospectively analyzed. Results: (1) The median age of the 7 patients was 28 years old (range: 26-33 years); 3 cases complained of abdominal pain (2 cases of huge pelvic or abdominal mass with multiple metastases), 2 cases of cough (1 case with superior vena cava syndrome), 1 case of facial swelling and pain, and 1 case of poor appetite. The median time from the onset of symptoms to initial visit was 30 days (range: 15-188 days). (2) Only 3 cases were diagnosed during pregnancy through biopsy, and the biopsy sites including right nasal vestibular mass, left supraclavicular lymph node and lung respectively. One case was suspected to be splenic marginal zone lymphoma through bone marrow puncture during pregnancy, and confirmed by pathological results observed in splenectomy specimens after termination of pregnancy. Three cases were diagnosed as NHL by pathological results of focus biopsy or partial tumor resection during cesarean section. Pathological types: 5 cases of diffuse large B cell lymphoma, one splenic marginal zone lymphoma and one nasal cavity natural killer (NK)/T cell lymphoma. Stages: 1 case of stage Ⅱ, 6 cases of stage Ⅳ. Pathological examination of placentas was performed for 4 patients after delivery, included one case with tumor metastasis to the placenta. (3) Among the 7 patients, 1 case was induced in the second trimester; 5 cases were terminated by cesarean section in the third trimester, all of which were premature; one case of full-term was delivered with forceps. All 6 neonates survived healthy. Treatments: 5 cases received chemotherapy after termination of pregnancy (included 1 case received autologous hematopoietic stem cell retransfusion therapy after chemotherapy), and 1 case received chemotherapy combined nasopharyngeal radiotherapy, and six cases survived without recurrence (follow-up until October 2022). The other case was a patient with hepatitis B virus infection and congenital heart disease who died of multiple organ failure 18 days after cesarean section. Conclusions: It is difficult to diagnose, necessary to pay attention to the complaints of pregnant women, and to actively carry out related examinations during pregnancy. When the lesion involves multiple organs, the possibility of lymphoma should be considered. Pregnancy with NHL is sensitive to chemotherapy. Even for advanced patients, good outcome could still be obtained after standardized treatment.