研究动态
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一只凤头鹦鹉(Cacatua moluccensis)患有双侧肘淋巴瘤和分枝杆菌感染症。

Bilateral Cubital Lymphoma and Mycobacteriosis in a Salmon-Crested Cockatoo (Cacatua moluccensis).

发表日期:2023 Mar
作者: Grace Pawsat, Nathan Hoggard, Abigail Duvall, Bente Flatland
来源: Protein & Cell

摘要:

一只32岁的雄性橘冠凤头鹦鹉(Cacatua moluccensis)通过细胞学被诊断为双侧肘淋巴瘤和分枝杆菌感染。聚合酶链式反应检测确认基因文森式分枝杆菌。随后,这个病人被安乐死。尸检组织病理学证实了两个诊断,发现多发性淋巴瘤、抗酸杆菌和所有滑膜关节的严重变性改变。通过协同抗原5的免疫组化染色,证实肘部肿块高百分比为B细胞淋巴瘤,符合B细胞淋巴瘤的特征。这个病例中出现两个主要疾病并行的情况是不寻常的,引发了一个问题,即这种病理学是否具有相互依赖的关系。分枝杆菌感染、严重退行性关节变化或两者都可能刺激淋巴细胞,最终导致淋巴瘤。如果在同伴鸟类中诊断出其中一种疾病,建议进行额外的筛查和监测以检测共病症。
A 32-year-old male salmon-crested cockatoo (Cacatua moluccensis) was diagnosed by cytology with bilateral cubital lymphoma and mycobacteriosis. Polymerase chain reaction assay testing confirmed Mycobacterium genavense. This patient was subsequently humanely euthanized. Postmortem histopathology confirmed both diagnoses with findings of multicentric lymphoma, acid-fast bacilli, and severe degenerative changes in all synovial joints examined. Immunohistochemical staining for paired box protein 5 of the cubital mass was positive for a high percentage of B-cell lymphocytes, consistent with B-cell lymphoma. This unusual case of two major diseases presenting concurrently in one patient raises the question of whether the pathogenesis could have an interdependent relationship. Mycobacteriosis, severe degenerative joint changes, or both may have stimulated lymphocytes, eventually leading to lymphoma. Additional screening and monitoring for comorbidities may be advised if 1 of these diseases are diagnosed in companion avian species.