癌症是一种系统性疾病，涉及恶性细胞内在和外在的代谢适应。大部分研究往往着重于阐明原发肿瘤微环境中的代谢易感性，而很少涉及转移微环境。本文观点文章中，我们讨论了癌细胞与肿瘤微环境之间在局部和全身层面上的代谢交互作用。我们探讨了原发肿瘤分泌物对在预转移巢形成期间代谢和表观遗传重编程远离恶性肿瘤的器官可能产生的影响，以及癌细胞在成功的转移定植中的作用。为了理解预转移巢形成的过程，我们推测癌症如何利用组织实质的固有再生倾向在转移定植期间实现转移。版权所有 © 2023 Elsevier Inc.。保留所有权利。

Cancer is a systemic disease that involves malignant cell-intrinsic and -extrinsic metabolic adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities in the primary tumor microenvironment, leaving the metastatic microenvironment less explored. In this opinion article, we discuss the current understanding of the metabolic crosstalk between the cancer cells and the tumor microenvironment, both at local and systemic levels. We explore the possible influence of the primary tumor secretome to metabolically and epigenetically rewire the nonmalignant distant organs during prometastatic niche formation and successful metastatic colonization by the cancer cells. In an attempt to understand the process of prometastatic niche formation, we have speculated how cancer may hijack the inherent regenerative propensity of tissue parenchyma during metastatic colonization.Copyright © 2023 Elsevier Inc. All rights reserved.