口腔癌是斯里兰卡男性中最常见的癌症。放射治疗是口腔癌的常见治疗方法，但这会影响口腔健康相关生活质量（OHRQOL）。本研究评估了单独接受此治疗或伴随化疗的口腔癌患者的OHRQOL及其从基线到放疗最后一周和放疗后三个月的变化。在等待单独接受放疗或化疗的90例口腔癌患者中进行了前瞻性纵向研究。使用欧洲研究与治疗癌症组织生物学质量生活问卷口腔健康模块（EORTC QLQ-OH15）的修改过的僧伽罗語版收集有关放疗前OHRQOL的数据。还记录了社会人口学和临床数据。对同一患者队列进行随访，评估了他们在放疗最后一周和放疗后三个月的OHRQOL。修改后的EORTC QLQ-OH15将OHRQOL评估分为三个领域：“进食问题”、“牙龈和言语问题”和“疼痛”，以及一个名为“牙齿”的项目。样本中大多数（88％）为男性。舌前两侧（40％）和颊黏膜（22％）是最常见的部位。在基线、放疗最后一周和放疗后三个月，“进食问题”领域的中位分数分别为20（IQR = 6.7-33.3），100（IQR = 86.9-100.0）和66.7（IQR = 46.7-93.3）。“牙龈和言语问题”在放疗最后一周（中位数50.0，IQR 25.0-58.3）比放疗后三个月（中位数8.3，IQR 0.0-33.3）更高。时间段之间的OHRQOL变化在统计学上具有显着性（p <0.05）。基线OHRQOL与“牙龈和言语问题”领域和“牙齿”项目有关，被确定为影响放疗最后一周OHRQOL的重要因素。单独接受放疗或化疗的口腔癌患者的OHRQOL从基线水平恶化到放疗最后一周，但在放疗后三个月得到改善。然而，三个月后，OHRQOL并没有恢复到基线水平。放疗最后一周的OHRQOL受基线OHRQOL、婚姻状况和转移部位的影响。©2023.作者。

Oral cancer is the number one cancer among males in Sri Lanka. Radiotherapy is a common treatment modality for oral cancer, but this can affect oral health related quality of life (OHRQOL). This study assessed the OHRQOL and its changes from baseline to the last week of radiotherapy and three months post radiotherapy among oral cancer patients who received this treatment alone or with chemotherapy.A prospective longitudinal study was conducted among 90 oral cancer patients awaiting for radiotherapy alone or with chemotherapy. The modified Sinhala version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Oral Health Module (EORTC QLQ-OH15) was used to gather data related to OHRQOL before radiotherapy. Socio-demographic and clinical data were also recorded. The same cohort of patients were followed up and assessed their OHRQOL during the last week of radiotherapy and three months post radiotherapy. The Modified EORTC QLQ-OH15 assesses the OHRQOL under three domains namely 'Eating problem', 'Gum and speech problem' and 'Soreness', and one item named as 'Teeth'.The majority of the sample (88%) was males. The anterior two-thirds of the tongue (40%) and buccal mucosa (22%) were the most common sites. The median scores of 'Eating problem' domain at baseline, last week of radiotherapy and three months post radiotherapy were 20 (IQR = 6.7-33.3), 100 (IQR = 86.9-100.0) and 66.7 (IQR = 46.7-93.3) respectively. 'Gum and speech problem' was higher during last week of radiotherapy (median, 50.0, IQR, 25.0-58.3) than three months post radiotherapy (median, 8.3, IQR, 0.0-33.3). The changes of OHRQOL between the time frames were statistically significant (p < 0.05). Baseline OHRQOL in relation to 'Gum and speech problem' domain and 'Teeth' item was identified as an influential factor for OHRQOL during last week of radiotherapy.The OHRQOL of oral cancer patients who received radiotherapy alone or with chemotherapy had deteriorated from the baseline level to the last week of radiotherapy but then improved at three months post radiotherapy. The OHRQOL however did not return to the baseline level three months post radiotherapy. OHRQOL during the last week of radiotherapy was influenced by the OHRQOL at baseline, civil status and sites of metastasis.© 2023. The Author(s).