身体活动和锻炼已被广泛认为能预防、治疗和控制多种非传染性疾病。在这个背景下，不计其数的临床和预临床证据显示了锻炼潜在的作用，不仅能预防和生存癌症，还包括改善生活质量，包括心理成分、骨健康和癌症幸存者的消瘦。本文综述了循环细胞外和颗粒泡（EVP）载体作为显化素，在邻近或远处的组织（如肿瘤、免疫、骨和肌肉细胞）中发挥多种积极作用的潜在作用。我们强调了在锻炼诱导的EVPs变化中，微RNA的新角度及其在肿瘤预防中的益处，因为微RNA可以与错综复杂的生理病理过程有关。在这篇文章中，我们指出了以下潜在的微RNA：miR-150-5p、miR-124、miR-486和miRNA-320a，它们在临床结果和肿瘤微环境的参与中均有先前的发现，能调节细胞间的通讯和肿瘤生长。例如，高强度间歇有氧运动计划似乎能增加正常体重或超重女性循环的EVP中miR-150的含量。根据循环EVPs中miR-150-5p的含量与结直肠癌预后密切相关，miR-150的异位表达可能会减少细胞增殖、侵袭和转移。除了生物活性miRNA参与循环EVPs中及其途径与临床和预临床发现相关的作用，本篇综述还旨在支持EVPs货运和锻炼对肿瘤学的影响的进一步研究。版权所有©2023 Siqueira、Batabyal、Freishtat和Cechinel。

Physical activity and exercise have been widely related to prevention, treatment, and control for several non-communicable diseases. In this context, there are innumerous pre-clinical and clinical evidence indicating the potential role of exercise, beyond cancer prevention and survival, improved quality of life, including on psychological components, bone health and cachexia, from cancer survivors is described as well. This mini-review raises the potential role of circulating extracellular and particles vesicles (EVPs) cargo, as exerkines, conducting several positive effects on adjacent and/or distant tissues such as tumor, immune, bone and muscle cells. We highlighted new perspectives about microRNAs into EVPs changes induced by exercise and its benefits on malignancies, since microRNAs can be implicated with intricated physiopathological processes. Potential microRNAs into EVPs were pointed out here as players spreading beneficial effects of exercise, such as miR-150-5p, miR-124, miR-486, and miRNA-320a, which have previous findings on involvement with clinical outcomes and as well as tumor microenvironment, regulating intercellular communication and tumor growth. For example, high-intensity interval aerobic exercise program seems to increase miR-150 contents in circulating EVPs obtained from women with normal weight or overweight. In accordance circulating EVPs miR-150-5p content is correlated with prognosis colorectal cancer, and ectopic expression of miR-150 may reduce cell proliferation, invasion and metastasis. Beyond the involvement of bioactive miRNAs into circulating EVPs and their pathways related to clinical and preclinical findings, this mini review intends to support further studies on EVPs cargo and exercise effects in oncology.Copyright © 2023 Siqueira, Batabyal, Freishtat and Cechinel.