Annexin A蛋白家族：着重研究癌症的发生、进展和治疗。
Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer.
发表日期：2023
作者：
Huhu Zhang, Zhe Zhang, Tingting Guo, Guang Chen, Guoxiang Liu, Qinghang Song, Guichun Li, Fenghua Xu, Xiaolei Dong, Fanghao Yang, Can Cao, Di Zhong, Shuang Li, Ya Li, Mengjun Wang, Bing Li, Lina Yang
来源：
Frontiers in Cell and Developmental Biology
摘要：
ANNX蛋白家族是一种着名的组织特异性多基因家族，编码Ca2+磷脂结合蛋白。大量的文献已经报道了ANXA蛋白在各种恶性疾病中的异常表达，包括癌症、动脉硬化和糖尿病。作为癌症中的重要调控分子，ANXA蛋白在癌症进展、增殖、侵袭和转移中起着至关重要的作用。本综述简要总结了它们在不同类型的癌症中的结构、生物学特性和功能的最新研究，并进一步讨论了将ANXA作为临床诊断和治疗癌症的新型靶点。版权所有 © 2023张、张、郭、陈、刘、宋、李、徐、董、杨、曹、钟、李、李、王、杨。
The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca2+ phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.Copyright © 2023 Zhang, Zhang, Guo, Chen, Liu, Song, Li, Xu, Dong, Yang, Cao, Zhong, Li, Li, Wang, Li and Yang.