白细胞介素2家族包括6种细胞因子，即IL-2、IL-15、IL-4、IL-7、IL-9和IL-21，所有这些细胞因子都共享一个γ链。 IL-2家族的许多细胞因子已被报道为免疫细胞活化的驱动力。因此，研究人员长期以来一直尝试各种方法研究细胞因子的抗肿瘤效果。然而，由于细胞因子的半衰期短、稳定性差、容易导致炎症风暴和治疗安全窗口狭窄，这一领域一直不温不火。近年来，随着蛋白质工程技术的快速发展，一些经过改造的细胞因子在肿瘤免疫治疗中具有显著的效果，显示出不可抗拒的发展趋势。在本文中，我们将讨论IL-2家族的当前研究，主要关注经过改造的细胞因子在肿瘤免疫治疗中的应用和成就。 版权所有©2023 Zhou、Quan、Liu、Shi、Wu、Zhang、Gao和Luo。

The Interleukin-2 Family contains six kinds of cytokines, namely IL-2, IL-15, IL-4, IL-7, IL-9, and IL-21, all of which share a common γ chain. Many cytokines of the IL-2 family have been reported to be a driving force in immune cells activation. Therefore, researchers have tried various methods to study the anti-tumor effect of cytokines for a long time. However, due to the short half-life, poor stability, easy to lead to inflammatory storms and narrow safety treatment window of cytokines, this field has been tepid. In recent years, with the rapid development of protein engineering technology, some engineered cytokines have a significant effect in tumor immunotherapy, showing an irresistible trend of development. In this review, we will discuss the current researches of the IL-2 family and mainly focus on the application and achievements of engineered cytokines in tumor immunotherapy.Copyright © 2023 Zhou, Quan, Liu, Shi, Wu, Zhang, Gao and Luo.