在前列腺腺癌中，肿瘤基质和上皮细胞在肿瘤进展中都扮演着重要的角色。转化生长因子β（TGF-β）是前列腺癌晚期促进因子。矩阵金属蛋白酶2（MMP2）是一种降解细胞外基质的内肽酶，被认为在前列腺癌的生长和侵袭性方面过度表达。因此，研究旨在分析前列腺腺癌和邻近未受影响实质的上皮和基质中TGF-β和MMP2蛋白的表达。通过基于微阵列免疫组织化学的方法，分析了62个前列腺腺癌标本中上皮、肿瘤基质和邻近未受影响实质中TGF-β和MMP2表达的强度。结果显示，TGF-β在肿瘤基质中的表达较高（p=0.000），而在前列腺基质中则没有统计学意义。MMP2在肿瘤基质中的表达较高（p=0.000），而在前列腺上皮中没有统计学意义（p=0.096）。研究结果表明，肿瘤基质和上皮都在肿瘤进展中扮演着重要角色，并支持TGF-β和MMP2在前列腺腺癌进展中的潜在作用。

In prostate adenocarcinoma, both tumorous stroma and epithelium have important role in tumor progression. Transforming growth factor beta (TGF- β) is a promotor in advanced stages of prostate cancer. Matrix Metalloproteinase 2 (MMP2), the endopeptidase that degrades extracellular matrix is considered to be overexpressed in prostatic carcinoma related to its growth and aggressiveness. Therefore, the aim was to analyze the expression of proteins TGF- β and MMP2 between both epithelium and stroma of prostatic adenocarcinoma and adjacent unaffected parenchyma. The intensity of TGF- β and MMP2 expression in epithelium, tumorous stroma and adjacent unaffected parenchyma was analyzed in 62 specimens of prostatic adenocarcinoma by microarray-based immunohistochemistry. TGF- β was more expressed in tumorous than in prostate stroma (p =0.000), while no statistical significance in case of MMP2 (p = 0.097) was found. MMP2 was more expressed in tumorous than in prostate epithelium (p =0.000), while no statistical significance in case of TGF- β (p = 0.096) was observed. The study results indicate that both tumorous stroma and epithelium have a role in tumor progression and support potential role of TGF- β and MMP2 in prostatic adenocarcinoma progression.