近一半的成年急性骨髓性白血病（AML）患者被归类为细胞遗传学正常的急性骨髓性白血病（CN-AML）。Trophinin相关蛋白（TROAP）表达水平已被证明与几种癌症的预后有关，但在CN-AML患者的预后中仍不清楚。我们整合了来自4个数据集的CN-AML患者样本，分析TROAP表达与CN-AML生存率之间的关系。此外，我们调查了The Cancer Genome Atlas（TCGA）数据库中的92个AML患者，以分析TROAP表达与接受化疗的AML患者的生存率之间的关系。我们研究了TROAP表达与AML细胞系的药物敏感性之间的关系。 TROAP高表达的CN-AML患者与良好的事件自由生存（EFS）和总生存率（OS）有关。在接受化疗的AML患者中，高TROAP表达与良好的生存预后有关。此外，在白血病干细胞（LSC）+组中，TROAP基因的表达较低。在多种药物中，TROAP表达越低，IC50越低。 TROAP可作为CN-AML患者的独立预测因子，并可能成为CN-AML预后的潜在生物标志物。 TROAP表达水平与多种药物的药物敏感性密切相关。

Nearly half of adult acute myeloid leukemia (AML) patients were classified into cytogenetic normal acute myeloid leukemia (CN-AML). The expression level of Trophinin associated protein (TROAP) was proven to be associated with the prognosis of several cancers, but it is still unclear in the prognosis of patients with CN-AML.We integrated CN-AML patients samples from 4 datasets to analyze the relationship between TROAP expression and the survival of CN-AML. In addition, we investigated 92 AML patients of The Cancer Genome Atlas (TCGA) database to analyze the relationship between TROAP expression and the survival of AML patients received chemotherapy. We investigated the relationship between the expression of TROAP and drug sensitivity in AML cell lines.CN-AML patients with high TROAP expression were related to good event-free survival (EFS) and overall survival (OS). In AML patients received chemotherapy, high TROAP expression was associated with good survival prognosis. Additionally, the expression of TROAP gene in leukemia stem cells (LSC) + group was lower. Among multiple drugs, the lower the expression of TROAP, the lower the IC50.TROAP could serve as an independent predictor of CN-AML patients and could act as a potential biomarker for the prognosis of CN-AML. TROAP expression levels were closely correlated with the drug sensitivity of multiple drugs.