癌症相关转移是发病率和死亡率的主要原因。然而，其潜在的生物学机制仍不清楚。预防或延迟转移的努力需要深入了解基础分子机制。然而，癌症生物学研究的持续进展已经提高了对一些分散过程分子基石的全面理解。然而，转移研究中新兴范例的出现直观地认识到了遗传、表观遗传、外在特征和肿瘤微环境在转移启动、进展和殖民化中的作用。在前往目标部位的过程中，分散的肿瘤细胞与多种蛋白质和细胞相互作用。识别转移程序背后的机制对于开发有效和高效的治疗干预措施至关重要。在本综述中，我们讨论了在转移和器官恶性趋势领域的最新进展的详细信息，并强调了遗传、表观遗传、外泌体、昼夜节律、微生物组、整合素和其他粘附分子以及趋化因子在转移事件调节中的作用。

Cancer associated metastasis is the primary cause of morbidity and mortality. Yet, its underlying biological mechanism remains poorly understood. Efforts to prevent or delay metastasis require a deep understanding of the underlying molecular mechanisms. However, continues advancement in cancer biology research has improved the comprehensive understanding of some of the molecular keystones of dissemination process. However, the emergence of new paradigms in the study of metastasis intuitively recognizes the involvement of genetics, epigenetics, extrinsic traits and tumor microenvironment in metastatic initiation, progression and colonization. On its way to the target site, the disseminated tumor cells interact with multiplex of proteins and cells. Identification of mechanisms underlying metastatic program is crucial for developing effective and efficient therapeutic interventions. In this review, we discuss details about recent advancements in the field of metastasis and organotropism, also highlights the role of genetics, epigenetics, exosomes, circadian rhythm, microbiome, integrins and other adhesion molecules, and chemokines in the regulation of metastatic events.