本研究旨在探讨T-cadherin与程序化死亡配体1（PD-L1）之间的相关性，以及它们在人乳头瘤病毒（HPV）阴性头颈鳞状细胞癌（HNSCC）患者中的预后价值。采用免疫组化染色技术确立T-cadherin和PD-L1的蛋白表达情况，采用Spearman线性相关分析确定它们之间的关系，采用Kaplan-Meier分析绘制总生存期（OS）和无病生存期（DFS）曲线，采用Cox比例风险回归分析进行单因素和多因素分析。结果显示T-cadherin和PD-L1的蛋白表达呈负相关（r = -0.760，p <0.001），T-cadherin的阳性表达与更好的OS（p <0.001）和DFS（p <0.001）相关，而PD-L1的阳性表达与更差的OS（p = 0.002）和DFS（p <0.001）相关。T-cadherin和PD-L1的表达是OS和DFS的独立预后因子。总之，T-cadherin和PD-L1的表达在HPV阴性HNSCC患者中具有较大的负相关性和独立的预后因子。© 2023 Wiley Periodicals LLC.

This study aimed at exploring the correlation between T-cadherin and programmed death-ligand 1 (PD-L1), as well as their prognostic value in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC).Immunohistochemical staining was used to identify the protein expression of T-cadherin and PD-L1. Spearman linear correlation analysis was used to determine their association. Kaplan-Meier analysis was utilized to plot overall survival (OS) and disease-free survival (DFS) curves. Cox proportional hazards regression was used to conduct univariate and multivariate analysis.The results showed a negative association between protein expression of T-cadherin and PD-L1 (r = -0.760, p < 0.001), positive expression of T-cadherin was associated with a better OS (p < 0.001) and DFS (p < 0.001), while positive PD-L1 expression was associated with a worse OS (p = 0.002) and DFS (p < 0.001). The expression of T-cadherin and PD-L1 were independent prognostic predictors for OS and DFS.In conclusion, expression of T-cadherin and PD-L1 were largely inversely correlated and independent prognostic factors for patients with HPV-negative HNSCC.© 2023 Wiley Periodicals LLC.