血管新生确实是癌瘤，包括喉癌发展中不可或缺的过程。因此，这项研究（AngLaC）旨在确定喉癌患者中与血管新生相关的生物标志物的候选者。前瞻性对照队列研究。三级转诊中心。进行了关于喉癌中与血管新生相关的基因的体外分析，以确定候选生物标志物。通过酶联免疫吸附法测定了喉癌患者以及年龄和性别匹配的对照组的候选生物标志物的血清水平。研究了生物标志物与临床参数的相关性。研究包括60名喉癌患者和20名健康对照者。患者组的骨桥蛋白、IGFBP-3、VEGF、sVEGFR-1和VEGFR-2血清水平显著高于对照组（分别为p < .001，p ≤ .001，p < .001，p < .01，p < .01）。高水平的骨桥蛋白和sVEGFR-1与局部复发有关（分别为p = .024，p = .016）。在探查的分子中，IGFBP-3具有最高的诊断敏感性（81.4％）和特异性（80％）（p < .001）。高水平的sVEGFR-1和低水平的VEGFR-2与不良总生存率有关（分别为p = .037，p = .027）。高水平的骨桥蛋白和sVEGFR-1与疾病特异性生存率较低有关（分别为p = .035，p = .018）。在喉癌中，高水平的sVEGFR-1和骨桥蛋白以及低水平的VEGFR-2在生存方面被证明是不良预后因素。与正常人群相比，VEGF、sVEGFR1、VEGFR2、IGFBP-3和骨桥蛋白水平在喉癌患者中明显升高。需要进一步研究骨桥蛋白和sVEGFR-1以确定它们与复发的关联。©2023美国耳鼻喉科头颈外科基金会（American Academy of Otolaryngology-Head and Neck Surgery Foundation）。

Angiogenesis is indeed a vital process in the progression of carcinomas, including that of larynx. Therefore, this study (AngLaC) aimed to identify candidate angiogenesis-related biomarkers in laryngeal carcinoma patients.Prospective controlled cohort study.Tertiary referral center.In silico analyses of angiogenesis-related genes in laryngeal carcinoma were performed to determine candidate biomarkers. Serum levels of candidate biomarkers were determined via enzyme-linked immunosorbent assay in laryngeal carcinoma patients as well as in an age and gender-matched control group. The associations of the biomarkers with clinical parameters were investigated.The study included 60 laryngeal carcinoma patients and 20 healthy controls. The serum levels of osteopontin, IGFBP-3, VEGF, sVEGFR-1, and VEGFR-2 were significantly higher in the patient group (p < .001, p ≤ .001, p < .001, p < .01, p < .01, respectively). High osteopontin and sVEGFR-1 levels were associated with locoregional-recurrence (p = .024, p = .016, respectively). IGFBP-3 had the highest diagnostic sensitivity (81.4%) and specificity (80%) among the molecules that were investigated (p < .001). High sVEGFR-1 and low VEGFR-2 levels were associated with poor overall-survival (p = .037, p = .027, respectively). High osteopontin and sVEGFR-1 levels were associated with poor disease-specific survival rates (p = .035, p = .018, respectively).High serum levels of sVEGFR-1 and osteopontin as well as low serum levels of VEGFR-2 proved to be poor prognostic in terms of survival in laryngeal carcinoma. VEGF, sVEGFR1, VEGFR2, IGFBP-3, and osteopontin levels were found to be significantly increased in larynx cancer patients compared to the normal population. Further studies on osteopontin and sVEGFR-1 are required in order to determine their associations with recurrence.© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.