可靠地诊断或安全地排除浆液型输卵管上皮内癌（STIC），一种输卵管-卵巢高级别浆液性癌前病变（HGSC），对个体患者护理，更好地理解HGSC的肿瘤发生机制，并安全地研究预防输卵管卵巢癌的新策略至关重要。为了优化STIC的诊断，并增加其可重复性，我们开展了一个三轮德尔菲研究。在第一轮中，组建了由11个国家的34位妇科病理学家组成的国际专家小组，提供有关STIC诊断的输入，以制定一组声明。在第二轮中，小组成员在9点力克特评分表上评价他们对这些声明的认可程度。在第三轮中，小组成员再次评价之前未达成共识的声明，同时匿名披露其他小组成员的反应。最后，每位专家被要求批准或不批准一套共识声明。小组表明他们对64个陈述的认可程度。经过三轮之后，共有27个声明（42％）达成共识。这些声明涉及病理学家的整个诊断过程，包括处理和大体学（三个声明），显微镜检查（八个声明），免疫组化（九个声明），解释和报告（四个声明）以及其他杂项（三个声明）。最终的共识声明集由85％的专家批准。该研究提供了有关专家妇科病理学家对STIC诊断的当前临床实践的概述。专家的共识声明形成了一组建议的基础，这可能有助于更一致地诊断STIC。© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.

Reliably diagnosing or safely excluding serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo-ovarian high-grade serous carcinoma (HGSC), is crucial for individual patient care, for better understanding the oncogenesis of HGSC, and for safely investigating novel strategies to prevent tubo-ovarian carcinoma. To optimize STIC diagnosis and increase its reproducibility, we set up a three-round Delphi study.In round 1, an international expert panel of 34 gynecologic pathologists, from 11 countries, was assembled to provide input regarding STIC diagnosis, which was used to develop a set of statements. In round 2, the panel rated their level of agreement with those statements on a 9-point Likert scale. In round 3, statements without previous consensus were rated again by the panel while anonymously disclosing the responses of the other panel members. Finally, each expert was asked to approve or disapprove the complete set of consensus statements. The panel indicated their level of agreement with 64 statements. A total of 27 statements (42%) reached consensus after three rounds. These statements reflect the entire diagnostic work-up for pathologists, regarding processing and macroscopy (three statements); microscopy (eight statements); immunohistochemistry (nine statements); interpretation and reporting (four statements); and miscellaneous (three statements). The final set of consensus statements was approved by 85%.This study provides an overview of current clinical practice regarding STIC diagnosis amongst expert gynecopathologists. The experts' consensus statements form the basis for a set of recommendations, which may help towards more consistent STIC diagnosis.© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.