暴露在铜中已成为一个健康问题。我们旨在探讨血液铜浓度的广泛临床影响。共有376,346名高加索人被招募。我们在UK生物库中进行了一项Mendelian随机化和表型广泛关联研究（MR-PheWAS），以评估铜和各种结局之间的因果关系，并构建了一个蛋白质相互作用网络。我们发现血液铜浓度与总体人群中的五种疾病有关，男性中有九种疾病有关。MR分析表明，血液铜在五种疾病（总人群）中发挥了因果作用，包括前列腺癌（OR = 0.87，95％CI为0.77-0.98）、脑和神经系统的恶性和未知新生物（OR = 0.58，95％CI为0.38-0.89）以及高血压（OR = 0.94，95％CI为0.90-0.98）、本质性高血压（OR = 0.94，95％CI 为0.90-0.98）和脑和神经系统的癌症（OR = 0.63，95％CI为0.41-0.98）。对于男性来说，除了吞咽困难与血液铜浓度新关联（OR = 1.39，95％CI为1.18-1.63）之外，其他MR结果与总人群一致。此外，PPI网络显示血液铜与四种结果可能存在关系，即脑癌、前列腺癌、高血压和吞咽困难。血液铜可能与前列腺癌、脑和神经系统的恶性和未知癌症、高血压和吞咽困难有因果关联。考虑到铜可以调节，探索调节铜水平是否可用于优化健康结果可能具有公共健康重要性。在线版本包含10.1007/s43657-022-00052-3号补充材料。©2022年国际人体表型研究所（上海）。

Exposures to copper have become a health concern. We aim to explore the broad clinical effects of blood copper concentrations. A total of 376,346 Caucasian subjects were enrolled. We performed a Mendelian randomization and phenome-wide association study (MR-PheWAS) to evaluate the causal association between copper and a wide range of outcomes in UK Biobank, and we constructed a protein-protein interaction network. We found association between blood copper concentrations and five diseases in the overall population and nine diseases in male. MR analysis implicated a causal role of blood copper in five diseases (overall population), including prostate cancer (OR = 0.87, 95% CI 0.77-0.98), malignant and unknown neoplasms of the brain and nervous system (OR = 0.58, 95% CI 0.38-0.89), and hypertension (OR = 0.94, 95% CI 0.90-0.98), essential hypertension (OR = 0.94, 95% CI 0.90-0.98) and cancer of brain and nervous system (OR = 0.63, 95% CI 0.41-0.98). For male, except for dysphagia being newly associated with blood copper (OR = 1.39, 95% CI 1.18-1.63), other MR results were consistent with the overall population. In addition, the PPI network showed possible relationship between blood copper and four outcomes, namely brain cancer, prostate cancer, hypertension, and dysphagia. Blood copper may have causal association with prostate cancer, malignant and unknown neoplasms of the brain and nervous system, hypertension, and dysphagia. Considering that copper is modifiable, exploring whether regulation of copper levels can be used to optimize health outcomes might have public health importance.The online version contains supplementary material available at 10.1007/s43657-022-00052-3.© International Human Phenome Institutes (Shanghai) 2022.