放射治疗诱导的口腔粘膜炎（RIOM）和化疗诱导的口腔粘膜炎（CIOM）是癌症患者常见的并发症，会导致负面临床表现、降低生活质量和不满意的治疗效果。本研究旨在通过数据挖掘来确定可能的分子机制和候选药物。我们获得了与 RIOM 和 CIOM 相关的基因的初步列表，通过功能和富集分析深入研究了这些基因的详细信息。然后，利用药物基因互作数据库确定最终富集基因列表与已知药物的互作关系，并分析候选药物。本研究确定了 21 个可能在 RIOM 和 CIOM 中发挥重要作用的枢纽基因。通过我们的数据挖掘、生物信息学调查和候选药物选择，TNF、IL-6 和 TLR9 可能在疾病进展和治疗中发挥重要作用。此外，通过药物基因互作文献搜索，还选出了八种候选药物（olokizumab、氯喹、羟氯喹、阿达木单抗、依托妥昔单抗、戈利单抗、英夫利昔单抗和沙利度胺），作为治疗 RIOM 和 CIOM 的候选药物。 © 2023年。作者（们）独家授权给德国施普林格-自然出版集团旗下施普林格-施普林格出版社。

Radiotherapy-induced oral mucositis (RIOM) and chemotherapy-induced oral mucositis (CIOM) are common complications in cancer patients, leading to negative clinical manifestations, reduced quality of life, and unsatisfactory treatment outcomes.The present study aimed to identify potential molecular mechanisms and candidate drugs by data mining.We obtained a preliminary list of genes associated with RIOM and CIOM. In-depth information on these genes was explored by functional and enrichment analyses. Then, the drug-gene interaction database was used to determine the interaction of the final enriched gene list with known drugs and analyze the drug candidates.This study identified 21 hub genes that may play an important role in RIOM and CIOM, respectively. Through our data mining, bioinformatics survey, and candidate drug selection, TNF, IL-6, and TLR9 could play an important role in disease progression and treatment. In addition, eight candidate drugs (olokizumab, chloroquine, hydroxychloroquine, adalimumab, etanercept, golimumab, infliximab, and thalidomide) were selected by the drug-gene interaction literature search additionally, as candidates for treating RIOM and CIOM.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.