一个关于正电子辐射治疗系统剂量分布的蒙特卡罗研究。
A Monte Carlo study on dose distribution of an orthovoltage radiation therapy system.
发表日期:2023 Mar 20
作者:
Toshie Iseri, Yoshinori Tanabe, Ryouta Onizuka, Yuri Torigoe, Hiro Horikirizono, Kazuhito Itamoto, Hiroshi Sunahara, Harumichi Itoh, Kenji Tani, Munekazu Nakaichi
来源:
Brain Structure & Function
摘要:
重要的是规划放射治疗,并建立最佳剂量分布以减少副作用和损伤的可能性。由于在伴侣动物中计算正短波放射治疗剂量分布的商业可用工具不存在,我们开发了一种算法来完成这项工作,并使用肿瘤疾病病例验证了其特征。首先,我们使用蒙特卡罗方法在我们的诊所使用BEAMnrc开发了一种算法,计算正短波放射治疗(280 kVp;MBR-320,日立医疗公司,东京,日本)的剂量分布。使用蒙特卡罗方法开发,在脑肿瘤,头部鳞状细胞癌和猫鼻淋巴瘤中评估了肿瘤和正常器官的剂量分布。在所有脑肿瘤案例中,由于经过颅骨而导致的GTV接收平均剂量的平均值范围为处方剂量的36.2%至76.1%。在猫的鼻淋巴瘤中,用2毫米厚的铅板覆盖的眼睛,其对应的平均剂量比未覆盖的眼睛低71.8%和89.9%。这些发现对于在正短波放射治疗中进行知情决策具有用处,可以更有效和有针对性地照射,并允许详细的知情同意数据收集。© 2023年。澳大利亚物理科学和医学工程师学院。
It is important to plan radiotherapy treatment and establish optimal dose distribution to reduce the chances of side effects and injury. Because there are no commercially available tools for calculating dose distribution in orthovoltage radiotherapy in companion animals, we developed an algorithm to accomplish this and verified its characteristics using tumor disease cases. First, we used the Monte Carlo method to develop an algorithm to calculate the dose distribution of orthovoltage radiotherapy (280 kVp; MBR-320, Hitachi Medical Corporation, Tokyo, Japan) using BEAMnrc at our clinic. Using development of Monte Carlo method, dose distribution for tumor and normal organs were evaluated in brain tumors, squamous cell carcinomas of the head, and feline nasal lymphomas. In all cases of brain tumors, the mean dose delivered to the GTV ranged from 36.2 to 76.1% of the prescribed dose due to the decrease through the skull. In the nasal lymphoma in cats, the eyes with covered a 2 mm-thick lead plate, the respective average dose to the eyes was 71.8% and 89.9% less than that to the uncovered eyes. The findings may be useful for informed decision making in orthovoltage radiotherapy with more effective and targeted irradiation and data collection allowing detailed informed consent.© 2023. Australasian College of Physical Scientists and Engineers in Medicine.