乙型肝炎病毒相关的肝硬化并具有低病毒血症的病患代表了一个特殊的群体，由于他们患并发症的风险更高，因此可能受益于治疗。然而目前缺乏针对此人群治疗的有力证据。本研究分析了一个韩国中心627名乙型肝炎病毒相关的代偿性肝硬化历史队列的资料，报道了低病毒血症患者相较于无法检测到病毒者，其发生肝细胞癌的风险增加了2.4倍，这提供了支持该人群治疗的间接证据。该研究强调了在肝硬化发展之前治疗病患的重要性，以及需要有限时期的治愈性治疗。©2023年美国消化病学学院。

Patients with hepatitis B virus-related cirrhosis and low-level viremia represent a special group that might benefit from treatment because of their higher risk of complications. Evidence for the benefit of treatment in this population is lacking. The current study, which analyzed data of a historical cohort of 627 patients from a single Korean center with hepatitis B virus-related compensated cirrhosis, reported a 2.4-fold increased hepatocellular carcinoma risk among patients with low-level viremia compared with those with undetectable viremia provides indirect evidence in support of treatment for this population. The study underscores the importance of treating patients before the development of cirrhosis and the need for finite duration curative therapy.Copyright © 2023 by The American College of Gastroenterology.