回顾异苄内酯的药代动力学、药理学作用和机制。探索异苄内酯的治疗潜力。使用包括异苄内酯、药理效应、药代动力学和毒性在内的关键词在PubMed、Excerpta Medica Database（EMBASE）和Web of Science中搜索文献，以识别1992年至2022年发表的文章。异苄内酯具有许多生物活性，如抗炎、抗氧化、抗肿瘤、神经保护作用，无明显毒性。本文综述表明，异苄内酯在不同剂量下通过不同机制产生不同药理效应，可能是治疗炎症性疾病、神经退行性疾病和癌症的潜在药物候选者，并具有药用价值。异苄内酯具有多种药理活性和药用价值。然而，需要进一步研究确定其特定的细胞内作用位点和靶点，以充分了解其治疗机制，并为相关疾病的治疗提供参考。© 作者（们）2023。由牛津大学出版社代表英国皇家药剂师学会出版。

To review the pharmacokinetics, pharmacological action and mechanism of isoalantolactone (IAL). Explore the therapeutic potential of isoalantolactone.Keywords including isoalantolactone, pharmacological effects, pharmacokinetic and toxicity were used for literature search in PubMed, Excerpta Medica Database (EMBASE) and Web of Science, to identify articles published from 1992 to 2022.IAL has a great many obiological activities such as anti-inflammatory, antioxidant, antitumour, neuroprotection, with no obvious toxicity. This review suggests that IAL exerts different pharmacological effects with different mechanisms of action at different doses, and may be a potential drug candidate to treat inflammatory diseases, neurodegenerative diseases and cancer, with medicinal value.IAL has various pharmacological activities and medicinal values. However, further research is needed to determine its specific intracellular action sites and targets, so as to fully understand its therapeutic mechanism and provide a reference for the treatment of related diseases.© The Author(s) 2023. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society.