发展一种能够进行多模态成像指导联合治疗的纳米系统非常理想却具有挑战性。在这项研究中，我们介绍了一种由石墨烯氧化物嵌入空心介孔有机硅并装载药物多柔比星(DOX)和光敏剂四苯基卟啉(TPP)的多功能纳米颗粒(NPs)。这些NPs被温敏脂质体封装，一旦温度超过一定阈值便释放其内容物。生长在石墨烯氧化物(GO)表面的金属氧化物NPs扮演了多种角色，包括增强光热效率，作为对比剂提高磁共振成像的效果，增加光声成像的灵敏度和特异性，以及催化过氧化氢生成活性氧化物(ROS)。当局部注射时，HMONs-rNGO@Fe3 O4 /MnOx@FA/DOX/TPP NPs能有效富集于小鼠皮下Hela细胞瘤中。近红外(NIR)引起的光热/光动力/化疗联合治疗成功地抑制了肿瘤，没有明显的副作用。这项研究提出了一种独特的方法，用于开发针对癌症的多模态成像指导联合治疗。 ©2023年作者。细胞增殖由北京干细胞与再生医学研究所和约翰威利和儿子有限公司出版。

Developing a nanosystem that can perform multimodal imaging-guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide-grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of reactive oxygen species (ROS). When locally injected, the HMONs-rNGO@Fe3 O4 /MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near-infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging-guided combination therapy for cancer.© 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.