环境因素如紫外辐射和表观遗传变化是导致皮肤癌和衰老的主要因素之一。本综述提供了关于癌症发展、涉及的受体和治疗靶点方面的基本信息。多糖、多酚、蛋白质、核酸等生物高分子在正常细胞稳态调节方面发挥着重要作用。因此，探索生物高分子作为抗衰老制剂的作用以及这些制剂通过局部给药用于对抗癌症的可能性是相关的。由于紫外辐射是导致皮肤癌的主要因素之一，与衰老和癌症之间的受体联系表明胰岛素受体、褪黑素受体、类似Toll的受体、sirtuin1受体、肿瘤特异性T细胞受体和基于线粒体的靶向可以用于引导治疗以抑制癌症和预防衰老。基于生物高分子的纳米制剂通过俘获像姜黄素、白藜芦醇这样的药物，可以在相似的机制下预防癌症和衰老。某些蛋白质信号或钙和ROS信号通路对于癌症和衰老过程是不同的。线粒体DNA突变和端粒缩短与细胞能量学的改变积极参与衰老过程，可能引起线粒体功能障碍和表观遗传改变从而导致皮肤癌。因此，在衰老过程中使用生物高分子作为局部补充剂能够预防癌症。Copyright© Bentham Science Publishers; 如有任何疑问，请发送电子邮件至epub@benthamscience.net。

Environmental factors like UV radiation and epigenetic changes are one of the major factors for skin cancer that triggers aging. This review provides basic information on cancer development with respect to aging the receptors involved and the therapeutic targets.Biopolymers like polysaccharide, polyphenols, proteins, nucleic acid plays a vital role in regulation of normal cell homeostasis. It is therefore pertinent to explore the role of biopolymers as antiaging formulations and also the possibility of these formulations used against cancer via topical administrations.As UV radiation is one of the predominant factor in causing skin cancer the association of receptors between aging and cancer indicated that insulin receptor, melatonin receptor, toll like receptor, sirtuin 1 receptor, tumor specific T cell receptor and mitochondria based targeting can be used to direct therapeutics for suppression of cancer and prevent aging.Biopolymer based nanoformulations have tremendously progressed by entrapment of drugs like curcumin, resveratrol which can prevent cancer and aging in a similar mechanism.Certain protein signalling or calcium and ROS signalling pathways are different for cancer and aging process. The involvement of mitochondrial DNA mutation along with telomere shortening with a change in cellular energetics leading to genomic instability in aging process can also induce mitochondrial dysfunction and epigenetic alterations leading to skin cancer. Therefore, the use of biopolymers as a topical supplement during aging process can result in the prevention of cancer.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.