肾脏疾病主要在肾功能大幅下降后被诊断。慢性肾脏病是泌尿系统最常见的疾病之一，其由肾功能逐渐减少所定义。考虑到这个问题的隐匿性和晚期诊断，本研究旨在调查CKD的患病率及其与完全血细胞计数和肝功能测试的关联。在Tabari队列研究中共招募的人群中，选择了5822名没有糖尿病、高血压、心脏疾病、肾衰竭、癌症和病理性肥胖病史的受试者。使用肌酐清除率和膳食调整在肾脏疾病中的应用方案 (MDRD) 方程计算肾小球滤过率 (GFR)。不考虑主要原因，定义GFR下降小于60毫升/分钟/1.73平方米为CKD。总人口、男性和女性的CKD患病率分别为20.2％、16.8％和23.1％。多元模型显示，平均红细胞体积 (MCV) 的第三和第四四分位数以及淋巴细胞计数的第四四分位数的比率为0.78 (0.64, 0.95)、0.81 (0.67, 0.99) 和1.22 (1.01, 1.47)。相应的血尿素氮 (BUN) 的第四、第三和第二四分位数的比率分别为1.42 (1.14, 1.77)、1.76 (1.42, 2.19) 和2.79 (2.27, 3.43)。本研究表明，伊朗北部常见居民中（没有重大潜在疾病和过度肥胖），慢性肾脏病的患病率很高，特别是女性。此外，低MCV、低淋巴细胞和高BUN被发现是预测这种疾病的因素。版权所有：©2023国际预防医学杂志。

Kidney disorders are mainly diagnosed after a major decline in the renal function. Chronic kidney disease (CKD) is one of the most common disorders of the urinary system defined by gradual reduction of renal function. Considering the silent nature and late diagnosis of this problem, this study aims to investigate the prevalence of CKD and its association with Complete Blood Count (CBC) profile and liver function tests.Out of the total population enrolled in the Tabari cohort study, 5822 subjects without history of diabetes mellitus, hypertension, cardiac disease, renal failure, cancer, and pathologic obesity were selected. Glomerular filtration rate (GFR) was calculated using creatinine clearance as well as Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as GFR decline less than 60 ml/min/1.73 m2 regardless of its main cause.Prevalence of CKD in total population as well as men and women was 20.2%, 16.8%, and 23.1%, respectively. Multivariate models showed the odds ratios for third and fourth quartiles of Mean corpuscular volume (MCV) and also for the fourth quartile of the lymphocyte count as of 0.78 (0.64, 0.95), 0.81 (0.67, 0.99), and 1.22 (1.01, 1.47), respectively. Corresponding odds ratios for the fourth, third, and second quartiles of Blood Urea Nitrogen (BUN) were 1.42 (1.14, 1.77), 1.76 (1.42, 2.19), and 2.79 (2.27, 3.43), respectively.This study showed a high prevalence of CKD among the normal residents (without major underlying diseases and excessive obesity) in the north of Iran, especially among women. In addition, low MCV, low lymphocyte, and high BUN were detected as predictors of this disorder.Copyright: © 2023 International Journal of Preventive Medicine.