抗氧化剂和促氧化剂的不平衡在膀胱癌（BC）的癌变过程中起着关键作用。本研究旨在评估BC患者的血清抗氧化状态，并确定其在组织病理学评估后诊断和进展潜力考虑方面的潜在用途。横断面研究纳入了90例BC患者，分为Ta、T1和T2-T4阶段亚组，根据癌症进展潜力分为低级别（LG）和高级别（HG）亚组。对照组（CG）包括30名健康志愿者。使用分光光度法和标准实验室测试确定抗氧化状态。与CG相比，BC患者的血清超氧化物歧化酶活性显著高于癌症阶段（p <0.001）。T2-T4亚组的过氧化氢酶活性最高，显著高于Ta（p <0.01）和T1（p <0.05）亚组。与CG相比，BC组的血清白蛋白水平显著降低（p <0.001）。此外，T2-T4亚组的血清白蛋白水平显著低于T1和Ta亚组（p <0.01）。只有肿瘤大小与血清白蛋白水平之间存在显著负相关（r =-0.386，p <0.01）。过氧化氢酶活性在HG亚组中较高（p = 0.009），而胆红素水平在LG亚组中较高（p = 0.035）。在区分LG和HG BC亚组的患者方面，过氧化氢酶活性的最佳截断值为≥11.96 IU / L，其特异性和敏感性分别为51.1％和82.2％。对于计算出的最佳截断值≥11.95μmol / L，胆红素水平的特异性为44.1％，敏感性为80.0％。更有侵袭性的BC阶段和更大的进展潜力与酶促抗氧化剂活性的增加和非酶促抗氧化剂容量的降低有关，可能表明抗氧化剂在预测和监测疾病轨迹方面可能发挥作用。© 2022亚洲泌尿外科杂志编辑部。由Elsevier B.V.进行制作和托管。

The imbalance of antioxidants and pro-oxidants plays a crucial role in the carcinogenesis of bladder cancer (BC). This study aimed to evaluate serum antioxidant status in patients with BC and determine its potential use in the diagnosis and progression potential considerations following histopathological assessment.A cross-sectional study included 90 patients with BC, divided into Ta, T1, and T2-T4 stage subgroups, and according to cancer progression potential, into low-grade (LG) and high-grade (HG) subgroups. The control group (CG) included 30 healthy volunteers. Antioxidant status was determined using the spectrophotometric method and standard laboratory tests.Serum superoxide dismutase activity was significantly higher in BC patients regarding cancer stage in comparison to the CG (p<0.001). Catalase activity was highest in T2-T4 subgroup and was significantly higher compared to the Ta (p<0.01) and T1 (p<0.05) subgroups. Serum albumin level was significantly lower in the BC group compared to the CG (p<0.001). In addition, it was significantly lower in T2-T4 subgroup compared to T1 and Ta subgroups (p<0.01). A significant negative correlation was found between tumor size and serum albumin level only (r=-0.386, p<0.01). Catalase activity was higher in HG subgroup (p=0.009), while bilirubin level was higher in LG subgroup (p=0.035). The optimal cut-off value of catalase activity in differentiating patients with LG and HG BC subgroups was ≥11.96 IU/L, and the specificity and sensitivity were 51.1% and 82.2%, respectively. Bilirubin level, for a calculated optimal cut-off value of ≥11.95 μmol/L, had a specificity of 44.1% and sensitivity of 80.0%.More invasive stages of BC with greater progression potential are associated with an increase in enzymatic antioxidant activity and a decrease in non-enzymatic antioxidant capacity. It may suggest a possible role of antioxidants in the prediction and monitoring of illness trajectory.© 2022 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.