研究动态
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现代脂质体纳米囊泡免疫治疗在癌症治疗中的进展:综述。

Recent advances in the liposomal nanovesicles based immunotherapy in the treatment of cancer: A review.

发表日期:2023 Feb
作者: Yahya Alhamhoom, Greeshma Kakinani, Mohamed Rahamathulla, Riyaz Ali M Osmani, Umme Hani, Kamal Yoonus Thajudeen, G Kiran Raj, Devegowda V Gowda
来源: Immunity & Ageing

摘要:

免疫治疗与化疗、靶向输送、放射治疗和手术一起已成为最常见的癌症治疗方法。癌症免疫学的目标是利用身体的免疫系统来对抗肿瘤并产生强大的抗肿瘤免疫反应。在过去几年中,免疫检查点抑制剂和嵌合抗原受体修饰的T细胞在癌症免疫治疗方面取得了实质性进展。通过增强细胞特异性输送和免疫反应,纳米载体如脂质体具有增强更大免疫反应的能力。由于脂质体可以装载亲水性和疏水性药物并保护内核内装的免疫治疗药剂,因此它们比其他纳米输送系统更有优势,能够显着提高抗肿瘤治疗的疗效并解决多种癌症免疫疗法可能出现的问题。由于脂质体可以准确和及时地将免疫治疗输送到特定的靶向肿瘤中,对健康细胞几乎没有损伤,最大限度地提高免疫治疗的效果。脂质体也适用于与化疗、放疗和光疗等其他疗法同时输送药物。脂质体纳米粒子将被引入并作为一种具有很高精度的免疫治疗输送系统,成为一种可行的癌症治疗方法。本文重点介绍树突状细胞、T细胞、肿瘤和自然杀伤细胞以及巨噬细胞,概述了癌症免疫治疗的许多形式和脂质体纳米泡在癌症免疫治疗方面的前沿进展。 © 2022 作者
Immunotherapy, along with chemotherapy, targeted delivery, radiation and surgery has become one of the most common cancer treatments. The aim of cancer immunology is to use the bodys immune system to combat tumors and develop a robust antitumor immune response. In the last few years, immune checkpoint inhibitors and chimeric antigen receptor-modified T cells have made substantial advancements in cancer immunotherapy. By boosting cell type-specific delivery and immunological responses, nanocarriers like liposomes have the ability to enhance greater immune responses. The efficacy of anti-tumor therapeutics is being significantly improved as liposomes can assist in resolving a number of issues that can arise from a variety of cancer immunotherapies. Since, liposomes can be loaded with both hydrophilic and hydrophobic drugs and protect the immunotherapeutic agents loaded inside the core, they offer significant advantages over other nano delivery systems. The use of liposomes for accurate and timely delivery of immunotherapies to particular targeted neoplasms, with little or no injury to healthy cells, maximizes immunotherapy efficacy. Liposomes are also suitable vehicles for delivering medications simultaneously with other therapies such as chemotherapy, radiation, and phototherapy. Liposomal nanoparticles will be introduced and used as an objective immunotherapy delivery system for great precision, making them a viable cancer treatment approach.With an emphasis on dendritic cells, T cells, tumor and natural killer cells, and macrophages; outline of many forms of immune-therapies in oncology and cutting-edge advances in liposomal nanovesicles for cancer immunotherapy are covered in this review.© 2022 The Author(s).