研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

基于影像导航的经皮和经动脉治疗方案用于原发性和转移性肺癌。

Image-Guided Percutaneous and Transarterial Therapies for Primary and Metastatic Lung Cancer.

发表日期:2023
作者: Arian Mansur, Tushar Garg, Juan C Camacho, Peiman Habibollahi, F Edward Boas, Fereshteh Khorshidi, Ji Buethe, Nariman Nezami
来源: Bone & Joint Journal

摘要:

肺癌是全球癌症死亡率的主要原因。相当大比例的肺癌患者不适合手术,并必须采取其他治疗方案。像介入放射学这样的领域的快速技术进展为图像引导的经皮和经动脉疗法治疗原发和转移性肺癌开辟了有效的治疗途径。消融疗法的基本依据在于有针对性地传递能量可引起肿瘤破坏和病理性坏死。图像引导的经皮热消融疗法是在肝脏、肾脏、骨骼、甲状腺或子宫病灶的局部治疗中已被证实的技术。在肺部,肺消融的三个主要适应症包括局部治愈意图、在寡转移病例中实现化疗休假的策略,以及最近发展的寡进展性疾病。经动脉治疗包括一系列基于导管的治疗方法,涉及通过供血动脉将栓塞和/或化疗药物直接投向靶肿瘤。本文综合评述了各种可用技术,并讨论了它们在原发和转移性肺癌中的应用和相关并发症。
Lung cancer is the leading cause of cancer mortality in the world. A significant proportion of patients with lung cancer are not candidates for surgery and must resort to other treatment alternatives. Rapid technological advancements in fields like interventional radiology have paved the way for valid treatment modalities like image-guided percutaneous and transarterial therapies for treatment of both primary and metastatic lung cancer. The rationale of ablative therapies relies on the fact that focused delivery of energy induces tumor destruction and pathological necrosis. Image-guided percutaneous thermal ablation therapies are established techniques in the local treatment of hepatic, renal, bone, thyroid, or uterine lesions. In the lung, the 3 main indications for lung ablation include local curative intent, a strategy to achieve a chemoholiday in oligometastatic disease, and recently, oligoprogressive disease. Transarterial therapies include a set of catheter-based treatments that involve delivering embolic and/or chemotherapeutic agents directed into the target tumor via the supplying arteries. This article provides a comprehensive review of the various techniques available and discusses their applications and associated complications in primary and metastatic lung cancer.