受损肺功能与认知下降风险增加有关。F-18荧光脱氧葡萄糖（FDG）PET是一种著名的神经退行 biomarker 用于痴呆症。我们研究了使用FDG PET在患有肺癌的患者中的肺部和脑部功能之间的关联。选取了102名没有自我报告神经精神障碍病史的肺癌患者的随机子样本，在治疗前接受了肺功能测验和FDG PET扫描。肺功能被分析为强制 vit​​al capacity和f ​​orced expiratory volume in the first second的百分比预测值（% pred）。血糖代谢用标准化摄取值（SUVs）在额叶，顶叶，颞叶和枕叶以及与认知相关的区域中进行测量。通过将每个区域中的SUV除以整个大脑SUV来计算区域SUV比率（SUVRs），然后将其与肺功能指数和临床变量进行评估。排除5名脑转移患者后，最终分析中包括97名患者（平均年龄67.7 ± 10.3岁）。平均FVC和平均FEV1分别为80.0％± 15.4％和77.6％± 17.8％。在调整了临床变量的数据后，FVC和FEV1均与所有脑区域的SUVR呈正相关。与认知相关的区域和其他区域之间的SUVR下降程度没有显著差异。受损肺功能与所有脑区域的葡萄糖代谢下降有关，这表明与葡萄糖代谢下降相关的认知下降可能是由于灌注减少所致。版权所有©2023 Wolters Kluwer Health，Inc. 保留所有权利。

Impaired lung function is associated with an increased risk for cognitive decline. F-18 fluorodeoxyglucose (FDG) PET is a well-known neurodegenerative biomarker for dementia. We investigated the association between lung and brain function using FDG PET in patients with lung cancer.A random sub-sample of 102 patients with lung cancer and without a self-reported history of neuropsychiatric disorders were recruited and underwent both lung function tests and FDG PET scans before treatment. Lung function was analyzed as the percentage predicted value (% pred) of forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1). FDG uptake was measured as standardized uptake values (SUVs) in the frontal, parietal, temporal, and occipital cortices and cognition-related regions. Regional SUV ratios (SUVRs) were calculated by dividing the SUV in each region by the whole-brain SUV and were then evaluated against lung function indices and clinical variables.After excluding five patients with brain metastases, 97 patients were included in the final analysis (mean age, 67.7 ± 10.3 years). Mean FVC and mean FEV1 were 80.0% ± 15.4% and 77.6% ± 17.8%, respectively. Both FVC and FEV1 were positively correlated with SUVRs in all brain regions after adjusting the data for clinical variables. The degree of decrease in SUVRs related to lung function was not significantly different between cognition-related regions and other regions.Impaired lung function was associated with decreased glucose metabolism in all regions of the brain, indicating that cognitive decline related to decreased glucose metabolism may be due to reduced perfusion.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.