基于肺功能测定的职业性肺病研究大多关注阻塞性或混合阻塞性/限制性结果。我们想要确定限制性肺功能模式（RSP）是否与职业和提高的死亡率相关。研究参与者包括18,145名具有人口统计和吸烟数据以及可重复进行的肺功能测定的工人。死亡分析队列包括15,445名已知生命状态和死亡原因的工人，截至2016年12月31日。分层分析探讨了RSP在人口统计和临床变量以及工种中的患病率。对吸烟、肥胖和合并症等重要混杂因素进行控制的对数二项回归模型探讨了RSP的危险因素。Cox回归模型探讨了肺功能测定类别的死亡风险。RSP的患病率非常高（28.6％）。RSP的死亡危险比为全因死亡1.50，心血管疾病1.86，呼吸系统疾病2.31，肺癌1.66。除了画家、机械师和屋顶工之外，所有建筑工种均相对于我们的内部参照组具有显着升高的RSP风险。肺部X线检查显示肺实质和胸膜变化与RSP显著相关。建筑工人独立于肥胖具有显着增加RSP风险。RSP患者不仅具有全因死亡的增加风险，还具有呼吸系统疾病、心血管疾病和肺癌的死亡风险增加。在职业医学和流行病学中应更加注重研究RSP。

Spirometry-based studies of occupational lung disease have mostly focused on obstructive or mixed obstructive/restrictive outcomes. We wanted to determine if restrictive spirometry pattern (RSP) is associated with occupation and increased mortality.Study participants included 18,145 workers with demographic and smoking data and repeatable spirometry. The mortality analysis cohort included 15,445 workers with known vital status and cause of death through December 31, 2016. Stratified analyses explored RSP prevalence by demographic and clinical variables and trade. Log-binomial regression models explored RSP risk factors while controlling for important confounders such as smoking, obesity, and comorbidities. Cox regression models explored mortality risk by spirometry category.Prevalence of RSP was very high (28.6%). Mortality hazard ratios for RSP were 1.50 for all causes, 1.86 for cardiovascular diseases, 2.31 for respiratory diseases, and 1.66 for lung cancer. All construction trades except painters, machinists, and roofers had significantly elevated risk for RSP compared to our internal reference group. RSP was significantly associated with both parenchymal and pleural changes seen by chest X-ray.Construction trade workers are at significantly increased risk for RSP independent of obesity. Individuals with RSP are at increased risk for all-cause mortality as well as mortality attributable to respiratory diseases, cardiovascular diseases, and lung cancer. RSP deserves greater attention in occupational medicine and epidemiology.© 2023 Wiley Periodicals LLC.