恶性高血压患者死亡的主要原因是肾衰竭。本文中，我们探讨了使用抗氧化分子如白藜芦醇改善氧化应激在治疗本质性和恶性高血压领域的前景。白藜芦醇是一种植物自然产生的强效抗氧化剂，具有促进健康的特性。本研究在NG-L-Arginine Methyl Ester（L-NAME）处理的自发性高血压大鼠（SHR）-恶性高血压大鼠（MHR）中调查了白藜芦醇作为一种具有抗氧化活性的多酚类化合物的治疗潜力。白藜芦醇显著改善了MHR肾组织中的氧化损伤，调节了抗氧化酶并抑制了促氧化因子。肾脏的增强抗氧化防御提高了肾功能并改善了这个靶器官的形态学变化。此外，白藜芦醇的保护性质还通过恢复氮氧化物（NO）途径来发挥作用。 结论：使用白藜芦醇的抗氧化治疗可能代表一种有前途的治疗方法，尤其是用于高血压，特别是恶性高血压的肾脏损伤。 版权所有©2022作者。出版由Elsevier Masson SAS。保留所有权利。

The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties.In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR).Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.