研究动态
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一种新的风险模型用于预测舌重建术后吞咽障碍:日本一项回顾性多中心研究。

A Novel Risk Model for Predicting Dysphagia after Tongue Reconstruction: A Retrospective Multicenter Study in Japan.

发表日期:2023 Mar 21
作者: Jun Araki, Keita Mori, Yoshichika Yasunaga, Tetsuro Onitsuka, Takashi Yurikusa, Minoru Sakuraba, Takuya Higashino, Kazunobu Hashikawa, Katsuhiro Ishida, Shunji Sarukawa, Atsumori Hamahata, Yoshihiro Kimata, Hiroshi Matsumoto, Yasunobu Terao, Hideki Yokogawa, Mitsuru Sekido, Hirotaka Asato, Shimpei Miyamoto, Ikuo Hyodo, Masahiro Nakagawa,
来源: PLASTIC AND RECONSTRUCTIVE SURGERY

摘要:

关于舌再建手术后的术后结果,目前没有达成共识。因此,我们开发了一种新的风险模型,用于预测舌再建手术后吞咽困难的发生率。该回顾性研究由日本口咽食管手术和重建分析组在31家癌症中心和大学医院开展。包括2009年至2013年期间接受舌癌切除术并进行舌再建的532名患者(男性390人[73.3%],女性142人[26.7%];手术时中位数年龄为60岁[范围,15-88岁])。通过单变量回归分析确定了独立风险因素,并将其转换为二元格式进行多元分析。每个风险因素都被赋予一个整数值,以计算总分数,从而量化摄食管依赖的风险。总体而言,54名患者(10.2%)在评估时需要使用摄食管。在单变量回归分析中,摄食管依赖的预测因素为年龄较大、美国麻醉学会身体状态较差、低体重指数、低血清白蛋白、高血压和糖尿病并存、舌缺损范围扩大、超出舌部切除、喉悬吊术、术后放疗以及无功能性牙齿等。在多元 logistic 回归分析中,年龄≥58.5岁、术后放疗、舌缺损范围更广、体重指数<21.27 kg/m² 分别获得了6、4、3和2分,总分最高为15分。我们的风险模型提供了一种数学工具,用于在舌再建手术之前估算术后摄食管依赖的个体风险。© 2023 全体作者。由 Wolters Kluwer Health, Inc. 代表美国整形外科医师协会出版。保留所有权利。
There is no consensus on the postoperative outcomes of tongue reconstruction. Therefore, we developed a novel risk model for predicting dysphagia after tongue reconstruction.This retrospective study was conducted by the Oral Pharyngeal Esophageal Operation and Reconstruction Analytical group across 31 cancer centers and university hospitals in Japan. A total of 532 patients (390 [73.3%] men and 142 [26.7%] women; median age at surgery: 60 years [range, 15-88 years]) who were diagnosed with oral tongue squamous cell carcinoma and underwent tongue reconstruction following glossectomy between 2009 and 2013 were included. Independent risk factors were identified using univariate regression analysis and converted to a binary format for multivariate analysis. An integer value was assigned to each risk factor to calculate a total score capable of quantifying the risk of feeding tube dependence.Overall, 54 patients (10.2%) required a feeding tube at the time of evaluation. Predictive factors for feeding tube dependence were advanced age, lower American Society of Anesthesiologists physical status, low body mass index, lower serum albumin, comorbid hypertension and diabetes, extended tongue defect, resection beyond the tongue, laryngeal suspension, postoperative radiation, and no functional teeth. In multivariate logistic regression analysis, age ≥58.5 years, postoperative radiation, wider tongue defect, and body mass index <21.27 kg/m 2 earned 6, 4, 3, and 2 points, respectively, for a maximum total score of 15.Our risk model provides a mathematical tool for estimating the individual risk of postoperative feeding tube dependence before tongue reconstruction.Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Plastic Surgeons. All rights reserved.