进化保守的Hippo信号通路在调节器官大小和组织稳态方面至关重要。在正常情况下，该通路的活性受到严格调控，因为其物理功能被精确地维持以控制细胞增殖速率。维护失败会导致各种肿瘤。我们对Hippo失调和肿瘤发生的机制的理解越来越精确，依赖于上游抑制剂或激活剂的出现以及将Hippo靶基因、突变和相关信号通路与表型联系起来的连接。在本综述中，我们通过探讨Hippo通路在肿瘤发生和进展中的关键机制，以及癌症治疗中的潜在靶向，总结了近期关于Hippo通路信号网络在肿瘤发生和进展中的研究报告。

Evolutionarily conserved, the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis. The activity of this pathway is tightly regulated under normal circumstances, since its physical function is precisely maintained to control the rate of cell proliferation. Failure of maintenance leads to a variety of tumors. Our understanding of the mechanism of Hippo dysregulation and tumorigenesis is becoming increasingly precise, relying on the emergence of upstream inhibitor or activator and the connection linking Hippo target genes, mutations, and related signaling pathways with phenotypes. In this review, we summarize recent reports on the signaling network of the Hippo pathway in tumorigenesis and progression by exploring its critical mechanisms in cancer biology and potential targeting in cancer therapy.