个体对炎症的反应不同。在乳腺癌幸存者中，疼痛、悲伤和疲劳是常见的炎症相关症状。压力可能会预测反应强度。本研究测试了乳腺癌幸存者是否在急性炎症反应期间承受更多社交或非社交急性或慢性压力的幸存者在疼痛、悲伤和疲劳方面是否更明显。总共，156名绝经后乳腺癌幸存者（年龄36-78岁，I-IIIA阶段，治疗结束后1-9年）被随机分配到伤寒疫苗/生理盐水安慰剂或安慰剂/疫苗序列中，在至少相隔1个月的2次分离的访问中接受接种。接种后的接下来8个小时，每隔90分钟采集一次他们的血液，以评估白细胞介素-6和白细胞介素-1受体拮抗剂（IL-1Ra）的水平。在每次采集血样后不久，她们评估了当前的疼痛、悲伤和疲劳程度。女性还完成了负面社交交换测试以评估慢性社交压力和特里尔慢性压力器表格以索引慢性普遍压力。在每次访问时，训练有素的实验员会进行日常应激事件清单的评估，以评估过去24小时内社交和非社交压力的暴露情况。在进行有关人口统计和行为方面的协变量的统计调整后，最一致的结果是，报告更多慢性社交压力的幸存者在IL-1Ra增加时报告更多的疼痛和悲伤。频繁和持续的社交压力可能会使神经系统对炎症的影响变得敏感，这可能对乳腺癌幸存者的慢性疼痛和抑郁风险产生潜在影响。版权所有©2023年国际疼痛研究协会。

Individuals respond differently to inflammation. Pain, sadness, and fatigue are common correlates of inflammation among breast cancer survivors. Stress may predict response intensity. This study tested whether breast cancer survivors with greater exposure to acute or chronic social or nonsocial stress had larger increases in pain, sadness, and fatigue during an acute inflammatory response. In total, 156 postmenopausal breast cancer survivors (ages 36-78 years, stage I-IIIA, 1-9 years posttreatment) were randomized to either a typhoid vaccine/saline placebo or the placebo/vaccine sequence, which they received at 2 separate visits at least 1 month apart. Survivors had their blood drawn every 90 minutes for the next 8 hours postinjection to assess levels of interleukin-6 and interleukin-1 receptor antagonist (IL-1Ra). Shortly after each blood draw, they rated their current levels of pain, sadness, and fatigue. Women also completed the Test of Negative Social Exchange to assess chronic social stress and the Trier Inventory of Chronic Stressors screen to index chronic general stress. At each visit, a trained experimenter administered the Daily Inventory of Stressful Events to assess social and nonsocial stress exposure within the past 24 hours. After statistical adjustment for relevant demographic and behavioral covariates, the most consistent results were that survivors who reported more chronic social stress reported more pain and sadness in response to IL-1Ra increases. Frequent and ongoing social stress may sensitize the nervous system to the effects of inflammation, with potential implications for chronic pain and depression risk among breast cancer survivors.Copyright © 2023 International Association for the Study of Pain.