脂肪噬菌体是通过溶酶体介导的途径选择性降解脂质，脂噬功能紊乱与许多肝病的病理标志有关。肝细胞中脂噬下调会导致脂滴（脂类小滴）异常积聚在肝细胞内，这是许多肝病的特征，如非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）。相反，唤醒肝星状细胞（HSCs）中的脂噬会与肝纤维化和肝硬化相关。癌细胞中的脂代谢再编程有助于肝癌的进展。在本文中，我们总结了近期关于脂噬装置各个组成部分的研究，这些部分可以调节其潜在的治疗作用，以对抗广泛的肝病。 ©2023。作者（们）以Springer Science+Business Media，LLC，Springer Nature的独家许可发布。

Lipophagy is a selective degradation of lipids by a lysosomal-mediated pathway, and dysregulation of lipophagy is linked with the pathological hallmark of many liver diseases. Downregulation of lipophagy in liver cells results in abnormal accumulation of LDs (Lipid droplets) in hepatocytes which is a characteristic feature of several liver pathologies such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Contrarily, upregulation of lipophagy in activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and cirrhosis. Lipid metabolism reprogramming in violent cancer cells contributes to the progression of liver cancer. In this review, we have summarized the recent studies focusing on various components of the lipophagic machinery that can be modulated for their potential role as therapeutic agents against a wide range of liver diseases.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.