人类乳头瘤病毒（HPV）相关的扁桃体癌与良好的疗效有关。本研究的目的是确定影响患有接受手术治疗的HPV阳性扁桃体癌患者远处转移的因素。本研究招募了76名于2010年1月至2021年12月之间接受原始手术治疗的HPV阳性扁桃体癌患者。随访中位数为43个月，其中12名（15.7％）患者有远隔失败。远隔转移的部位包括肺（n = 10）、肝（n = 1）和脑（n = 1）。多因素分析显示，高级T期（OR：13.94，95％CI：1.29-149.863，p = 0.003）和边缘累及（OR：5.96，95％CI：1.33-26.76，p = 0.02）是远隔转移的独立预测因子。整个组的五年疾病特异性生存率为85％。多元分析证实，远隔转移（风险比[HR]：12.688，95％CI：3.424-47.016；p < 0.001）和边缘累及（HR：6.243；95％CI：1.681-23.191；p = 0.006）是影响五年疾病特异性生存率的重要因素。HPV阳性扁桃体癌患者，在T期进展和手术切缘呈阳性时，存在远距离转移的风险，远隔转移和边缘累及是影响其生存的因素。 版权：© 2023 Shin等人。本文是在知识共享署名许可下发表的开放获取文章，允许在任何媒体下无限制使用、分发和复制，前提是原作者和来源得到了公认的功劳。

Human papilloma virus (HPV)-related tonsil cancer is associated with favorable outcomes.The purpose of this study was to define factors affecting distant metastasis in patients with surgically treated HPV-positive tonsil cancer.The present study enrolled 76 patients diagnosed with HPV-positive tonsil cancer who underwent primary surgery between January 2010 and December 2021.Twelve (15.7%) patients experienced a distant failure with a median follow-up time of 43 months. Sites of distant metastasis included the lung (n = 10), liver (n = 1), and brain (n = 1). Upon multivariate analysis, an advanced T stage (odds ratio [OR]: 13.94, 95% confidence interval [CI]: 1.29-149.863, p = 0.003) and margin involvement (OR: 5.96, 95% CI: 1.33-26.76, p = 0.02) were independent predictors of distant metastases. The five-year disease-specific survival for the entire cohort was 85%. The multivariate analysis confirmed that distant metastasis (hazard ratio [HR]: 12.688, 95% CI: 3.424-47.016; p < 0.001) and margin involvement (HR: 6.243; 95% CI: 1.681-23.191; p = 0.006) were significant factors associated with the five-year disease-specific survival.HPV-positive tonsil cancer patients with an advanced T stage and a positive surgical margin have a substantial risk of distant metastases. Distant metastasis and margin involvement are factors that affect their survival.Copyright: © 2023 Shin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.