肿瘤微环境（TME）在肿瘤进展、转移和治疗抵抗中发挥着重要作用。重新塑造TME最近被认为是一种有吸引力的肿瘤治疗策略。由于其复杂性和多样性，重塑TME仍面临巨大挑战。由于其药物负载能力、肿瘤积累能力、多因素可控性和持久客体分子释放能力的重大优势，介孔纳米药物输送系统（MNDDSs）已被广泛应用作为有效的抗肿瘤药物输送工具以及重建TME。本文综述了TME的组成和特点，以及TME与癌细胞之间的相互作用，并重点关注基于MNDDSs的药物输送策略在靶向重塑TME代谢和协同抗癌治疗中的重要作用。©2023.作者（S）。

Tumor microenvironment (TME) plays an important role in tumor progression, metastasis and therapy resistance. Remodeling the TME has recently been deemed an attractive tumor therapeutic strategy. Due to its complexity and heterogeneity, remodeling the TME still faces great challenges. With the great advantage of drug loading ability, tumor accumulation, multifactor controllability, and persistent guest molecule release ability, mesoporous nanodrug delivery systems (MNDDSs) have been widely used as effective antitumor drug delivery tools as well as remolding TME. This review summarizes the components and characteristics of the TME, as well as the crosstalk between the TME and cancer cells and focuses on the important role of drug delivery strategies based on MNDDSs in targeted remodeling TME metabolic and synergistic anticancer therapy.© 2023. The Author(s).