紫杉醇是治疗癌症的常用药物，但对男性生殖系统具有毒性影响。将抗氧化剂与紫杉醇联合使用已成为预防其副作用的策略。虽然姜黄素是一种抗氧化剂，但关于姜黄素对紫杉醇诱导的睾丸组织影响的数据仍缺乏。本研究旨在检测姜黄素对紫杉醇引起睾丸损伤的保护作用。在研究中，选择40只Wistar雄性大鼠进行研究，并随机分为4组（n：10）。对照组仅接受生理盐水，姜黄素组在实验期间持续接受姜黄素，紫杉醇组在实验的第1天、第7天、第14天和第21天共接受4次紫杉醇，姜黄素+紫杉醇组在实验期间持续接受姜黄素并在实验的第1天、第7天、第14天和第21天共接受4次紫杉醇。实验结束时，使用依托咪酯麻醉剂处死大鼠并取出其睾丸。从睾丸细胞中获取切片并使用苏木精和伊红染色，评估组织病理损伤。使用TUNEL法评估细胞凋亡。测量血清中的睾酮水平。使用Johnsen睾丸活检评分（JTBS）评估睾丸小管。使用彗星实验技术评估从输精管尾端取出的精子样品的DNA损伤。结果显示，紫杉醇组的睾丸组织受到严重损伤。而且，使用姜黄素和紫杉醇联合使用可减轻睾丸组织中的组织病理损伤。此外，根据JTBS的评估，姜黄素+紫杉醇组的睾丸小管值显著高于紫杉醇组（p<0.05）。与紫杉醇组相比，姜黄素+紫杉醇组的睾酮水平更高。DNA损伤也在姜黄素+紫杉醇组中显著降低（p<0.05）。研究结果表明，姜黄素可能对大鼠睾丸损伤具有保护作用。

Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects of paclitaxel. Although curcumin is an antioxidant, data concerning the effect of curcumin on paclitaxel-induced testis tissue are lacking. The present study was established to examine the protective impact of curcumin against testicular damage induced by paclitaxel.In the study, 40 Wistar albino male rats were used and randomly divided into 4 groups (n:10). The control group received only saline solution; the curcumin group received curcumin throughout the experiment; the paclitaxel group received a total of four doses of paclitaxel on days 1, 7, 14, and 21 of the experiment; curcumin + paclitaxel group received curcumin throughout the experiment and a total of four doses of paclitaxel on days 1, 7, 14, and 21 of the experiment. At the end of the experiment, the rats were decapitated under xylazine and ketamine anesthesia and their testicles were removed. The sections obtained from the testicles were stained with Hematoxylin & Eosin and histopathological damage was evaluated. The TUNEL method was applied to determine apoptotic cells. Testosterone levels were measured in the blood serum. The Johnsen testicular biopsy score (JTBS) was used to evaluate testicular tubules. DNA damage was evaluated in sperm samples taken from the ductus epididymis using the comet assay technique.Testicular tissue was severely damaged in the paclitaxel group. In the curcumin + paclitaxel group, it was determined that the administration of curcumin with paclitaxel reduced the histological damage in the testicular tissue. Moreover, according to the JTBS, the value was significantly higher in the testicular tubules (p < 0.05). Testosterone levels were higher in curcumin + paclitaxel group than in paclitaxel group. DNA damage also decreased significantly in curcumin + paclitaxel group when compared to paclitaxel group (p < 0.05).The results showed that curcumin may be protective against damage caused by paclitaxel in the testicles of rats.